Effects of atrioventricular conduction delay on the outcome of cardiac resynchronization therapy

Ying Hsiang Lee; Jia Hui Wu; Samuel J. Asirvatham; Freddy Del Carpio Munoz; Tracy Webster; Kelly L. Brooke; David O. Hodge; Heather J. Wiste; Paul A. Friedman; Yong Mei Cha

doi:10.1016/j.jelectrocard.2014.07.024

Effects of atrioventricular conduction delay on the outcome of cardiac resynchronization therapy

Ying Hsiang Lee, Jia Hui Wu, Samuel J. Asirvatham, Freddy Del Carpio Munoz, Tracy Webster, Kelly L. Brooke, David O. Hodge, Heather J. Wiste, Paul A. Friedman, Yong Mei Cha

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background and purpose First-degree atrioventricular (AV) block in relation to the outcome of cardiac resynchronization therapy (CRT) has not been well examined.

Methods Patients who received a CRT defibrillator or pacemaker between January 2002 and September 2010 at Mayo Clinic were classified into 2 groups: normal PR interval and prolonged PR interval. Standard sensed (100 milliseconds) and paced (130 milliseconds) AV delay was programmed after CRT. Clinical presentations and echocardiography were assessed before CRT and at a median of 6 months after CRT.

Results The normal PR interval group (n = 199) had greater improvements in heart failure functional class (mean [SD], 0.7 [0.8] vs 0.5 [0.9]; P =.03) and left ventricular ejection fraction (9.4% [12.4%] vs 5.9% [9.5%]; P =.007) than the prolonged PR group (n = 204).

Conclusion Compared with prolonged PR interval, the presence of normal PR interval was associated with a greater improvement in heart failure.

Original language	English (US)
Pages (from-to)	930-935
Number of pages	6
Journal	Journal of Electrocardiology
Volume	47
Issue number	6
DOIs	https://doi.org/10.1016/j.jelectrocard.2014.07.024
State	Published - Nov 1 2014

Keywords

Atrioventricular block
Cardiac resynchronization
Dyssynchrony
Heart failure
PR interval
Survival

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jelectrocard.2014.07.024

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title = "Effects of atrioventricular conduction delay on the outcome of cardiac resynchronization therapy",

abstract = "Background and purpose First-degree atrioventricular (AV) block in relation to the outcome of cardiac resynchronization therapy (CRT) has not been well examined.Methods Patients who received a CRT defibrillator or pacemaker between January 2002 and September 2010 at Mayo Clinic were classified into 2 groups: normal PR interval and prolonged PR interval. Standard sensed (100 milliseconds) and paced (130 milliseconds) AV delay was programmed after CRT. Clinical presentations and echocardiography were assessed before CRT and at a median of 6 months after CRT.Results The normal PR interval group (n = 199) had greater improvements in heart failure functional class (mean [SD], 0.7 [0.8] vs 0.5 [0.9]; P =.03) and left ventricular ejection fraction (9.4% [12.4%] vs 5.9% [9.5%]; P =.007) than the prolonged PR group (n = 204).Conclusion Compared with prolonged PR interval, the presence of normal PR interval was associated with a greater improvement in heart failure.",

keywords = "Atrioventricular block, Cardiac resynchronization, Dyssynchrony, Heart failure, PR interval, Survival",

author = "Lee, {Ying Hsiang} and Wu, {Jia Hui} and Asirvatham, {Samuel J.} and {Del Carpio Munoz}, Freddy and Tracy Webster and Brooke, {Kelly L.} and Hodge, {David O.} and Wiste, {Heather J.} and Friedman, {Paul A.} and Cha, {Yong Mei}",

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T1 - Effects of atrioventricular conduction delay on the outcome of cardiac resynchronization therapy

AU - Lee, Ying Hsiang

AU - Wu, Jia Hui

AU - Asirvatham, Samuel J.

AU - Del Carpio Munoz, Freddy

AU - Webster, Tracy

AU - Brooke, Kelly L.

AU - Hodge, David O.

AU - Wiste, Heather J.

AU - Friedman, Paul A.

AU - Cha, Yong Mei

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Background and purpose First-degree atrioventricular (AV) block in relation to the outcome of cardiac resynchronization therapy (CRT) has not been well examined.Methods Patients who received a CRT defibrillator or pacemaker between January 2002 and September 2010 at Mayo Clinic were classified into 2 groups: normal PR interval and prolonged PR interval. Standard sensed (100 milliseconds) and paced (130 milliseconds) AV delay was programmed after CRT. Clinical presentations and echocardiography were assessed before CRT and at a median of 6 months after CRT.Results The normal PR interval group (n = 199) had greater improvements in heart failure functional class (mean [SD], 0.7 [0.8] vs 0.5 [0.9]; P =.03) and left ventricular ejection fraction (9.4% [12.4%] vs 5.9% [9.5%]; P =.007) than the prolonged PR group (n = 204).Conclusion Compared with prolonged PR interval, the presence of normal PR interval was associated with a greater improvement in heart failure.

AB - Background and purpose First-degree atrioventricular (AV) block in relation to the outcome of cardiac resynchronization therapy (CRT) has not been well examined.Methods Patients who received a CRT defibrillator or pacemaker between January 2002 and September 2010 at Mayo Clinic were classified into 2 groups: normal PR interval and prolonged PR interval. Standard sensed (100 milliseconds) and paced (130 milliseconds) AV delay was programmed after CRT. Clinical presentations and echocardiography were assessed before CRT and at a median of 6 months after CRT.Results The normal PR interval group (n = 199) had greater improvements in heart failure functional class (mean [SD], 0.7 [0.8] vs 0.5 [0.9]; P =.03) and left ventricular ejection fraction (9.4% [12.4%] vs 5.9% [9.5%]; P =.007) than the prolonged PR group (n = 204).Conclusion Compared with prolonged PR interval, the presence of normal PR interval was associated with a greater improvement in heart failure.

KW - Atrioventricular block

KW - Cardiac resynchronization

KW - Dyssynchrony

KW - Heart failure

KW - PR interval

KW - Survival

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Effects of atrioventricular conduction delay on the outcome of cardiac resynchronization therapy

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Keywords

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