Effects of atrial natriuretic peptide on renin secretion in nonfiltering kidney

T. J. Opgenorth, John C Jr. Burnett, J. P. Granger, T. A. Scriven

Research output: Chapter in Book/Report/Conference proceedingChapter

34 Citations (Scopus)

Abstract

Studies were performed in normal dogs (n = 6) and dogs with nonfiltering kidneys (n = 8) to determine the effects of synthetic atrial natriuretic peptide (ANP) on renin secretion and renal hemodynamics in the presence and absence of a functional macula densa. In normal dogs, intrarenal infusion of ANP (0.3 μg·kg-1·min-1) resulted in a decrease in renin secretion from 325.5 ± 87.4 to 52.4 ± 29.4 ng/ml, despite a sustained decrease in arterial pressure. In contrast, in the nonfiltering kidney without a functional macula densa, ANP infusion did not inhibit renin secretion in this nonfiltering model. Adenosine, however, known to directly inhibit renin secretion, did decrease renin secretion in this nonfiltering model. The present studies document that, in the nonfiltering kidney, ANP has no inhibitory effect on renin secretion.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume250
Edition5
StatePublished - 1986

Fingerprint

Atrial Natriuretic Factor
Renin
Kidney
Dogs
Adenosine
Arterial Pressure
Hemodynamics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Opgenorth, T. J., Burnett, J. C. J., Granger, J. P., & Scriven, T. A. (1986). Effects of atrial natriuretic peptide on renin secretion in nonfiltering kidney. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology (5 ed., Vol. 250)

Effects of atrial natriuretic peptide on renin secretion in nonfiltering kidney. / Opgenorth, T. J.; Burnett, John C Jr.; Granger, J. P.; Scriven, T. A.

American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 250 5. ed. 1986.

Research output: Chapter in Book/Report/Conference proceedingChapter

Opgenorth, TJ, Burnett, JCJ, Granger, JP & Scriven, TA 1986, Effects of atrial natriuretic peptide on renin secretion in nonfiltering kidney. in American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 5 edn, vol. 250.
Opgenorth TJ, Burnett JCJ, Granger JP, Scriven TA. Effects of atrial natriuretic peptide on renin secretion in nonfiltering kidney. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 5 ed. Vol. 250. 1986
Opgenorth, T. J. ; Burnett, John C Jr. ; Granger, J. P. ; Scriven, T. A. / Effects of atrial natriuretic peptide on renin secretion in nonfiltering kidney. American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 250 5. ed. 1986.
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