Effects of atorvastatin (80 mg) therapy on quantity of epicardial adipose tissue in patients undergoing pulmonary vein isolation for atrial fibrillation

Filip Soucek, Naima Covassin, Prachi Singh, Lukas Ruzek, Tomas Kara, Mahmoud Suleiman, Amir Lerman, Celeste Koestler, Paul Andrew Friedman, Francisco Lopez-Jimenez, Virend Somers

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Epicardial adipose tissue (EAT) has been recognized as a sensitive marker of cardiometabolic risk. Recent evidence suggests efficacy of long-term statin therapy in reducing EAT in patients with coronary artery disease. Whether short-term statin therapy is associated with changes in the volume of EAT is currently unknown. A cohort of patients with atrial fibrillation who underwent pulmonary vein isolation were randomized to receive either 80 mg/day of atorvastatin (n = 38, 32 men, age 56 ± 11 years) or placebo (n = 41, 33 men, age 56 ± 10 years) for a 3-month period. EAT volume was assessed by cardiac computed tomography at baseline and at follow-up. Patients randomized to statin treatment exhibited a modest but significant decrease in median EAT volume (baseline vs follow-up: 92.3 cm3 [62.0 to 133.3] vs 86.9 cm3 [64.1 to 124.8], p 3 [55.5 to 110.9] vs 81.3 cm3 [57.1 to 110.5], p = NS). Changes in median systemic inflammatory markers and lipid profile were also seen with statin treatment: C-reactive protein (2.4 mg/L [0.7 to 3.7] vs 1.1 mg/L [0.5 to 2.7], p 2 [25 to 30] versus 27.6 kg/m2 [25.7 to 30.5], p = NS). No variations occurred in the placebo group. In conclusion, short-term intensive statin therapy significantly reduced the volume of EAT in patients with atrial fibrillation.

Original languageEnglish (US)
Pages (from-to)1443-1446
Number of pages4
JournalAmerican Journal of Cardiology
Volume116
Issue number9
DOIs
StatePublished - Nov 1 2015

Fingerprint

Pulmonary Veins
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Atrial Fibrillation
Adipose Tissue
Therapeutics
Placebos
C-Reactive Protein
Atorvastatin Calcium
Coronary Artery Disease
Tomography
Lipids

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{9ad52b197bcf432eb18a7b33acc4b308,
title = "Effects of atorvastatin (80 mg) therapy on quantity of epicardial adipose tissue in patients undergoing pulmonary vein isolation for atrial fibrillation",
abstract = "Epicardial adipose tissue (EAT) has been recognized as a sensitive marker of cardiometabolic risk. Recent evidence suggests efficacy of long-term statin therapy in reducing EAT in patients with coronary artery disease. Whether short-term statin therapy is associated with changes in the volume of EAT is currently unknown. A cohort of patients with atrial fibrillation who underwent pulmonary vein isolation were randomized to receive either 80 mg/day of atorvastatin (n = 38, 32 men, age 56 ± 11 years) or placebo (n = 41, 33 men, age 56 ± 10 years) for a 3-month period. EAT volume was assessed by cardiac computed tomography at baseline and at follow-up. Patients randomized to statin treatment exhibited a modest but significant decrease in median EAT volume (baseline vs follow-up: 92.3 cm3 [62.0 to 133.3] vs 86.9 cm3 [64.1 to 124.8], p 3 [55.5 to 110.9] vs 81.3 cm3 [57.1 to 110.5], p = NS). Changes in median systemic inflammatory markers and lipid profile were also seen with statin treatment: C-reactive protein (2.4 mg/L [0.7 to 3.7] vs 1.1 mg/L [0.5 to 2.7], p 2 [25 to 30] versus 27.6 kg/m2 [25.7 to 30.5], p = NS). No variations occurred in the placebo group. In conclusion, short-term intensive statin therapy significantly reduced the volume of EAT in patients with atrial fibrillation.",
author = "Filip Soucek and Naima Covassin and Prachi Singh and Lukas Ruzek and Tomas Kara and Mahmoud Suleiman and Amir Lerman and Celeste Koestler and Friedman, {Paul Andrew} and Francisco Lopez-Jimenez and Virend Somers",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.amjcard.2015.07.067",
language = "English (US)",
volume = "116",
pages = "1443--1446",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Effects of atorvastatin (80 mg) therapy on quantity of epicardial adipose tissue in patients undergoing pulmonary vein isolation for atrial fibrillation

AU - Soucek, Filip

AU - Covassin, Naima

AU - Singh, Prachi

AU - Ruzek, Lukas

AU - Kara, Tomas

AU - Suleiman, Mahmoud

AU - Lerman, Amir

AU - Koestler, Celeste

AU - Friedman, Paul Andrew

AU - Lopez-Jimenez, Francisco

AU - Somers, Virend

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Epicardial adipose tissue (EAT) has been recognized as a sensitive marker of cardiometabolic risk. Recent evidence suggests efficacy of long-term statin therapy in reducing EAT in patients with coronary artery disease. Whether short-term statin therapy is associated with changes in the volume of EAT is currently unknown. A cohort of patients with atrial fibrillation who underwent pulmonary vein isolation were randomized to receive either 80 mg/day of atorvastatin (n = 38, 32 men, age 56 ± 11 years) or placebo (n = 41, 33 men, age 56 ± 10 years) for a 3-month period. EAT volume was assessed by cardiac computed tomography at baseline and at follow-up. Patients randomized to statin treatment exhibited a modest but significant decrease in median EAT volume (baseline vs follow-up: 92.3 cm3 [62.0 to 133.3] vs 86.9 cm3 [64.1 to 124.8], p 3 [55.5 to 110.9] vs 81.3 cm3 [57.1 to 110.5], p = NS). Changes in median systemic inflammatory markers and lipid profile were also seen with statin treatment: C-reactive protein (2.4 mg/L [0.7 to 3.7] vs 1.1 mg/L [0.5 to 2.7], p 2 [25 to 30] versus 27.6 kg/m2 [25.7 to 30.5], p = NS). No variations occurred in the placebo group. In conclusion, short-term intensive statin therapy significantly reduced the volume of EAT in patients with atrial fibrillation.

AB - Epicardial adipose tissue (EAT) has been recognized as a sensitive marker of cardiometabolic risk. Recent evidence suggests efficacy of long-term statin therapy in reducing EAT in patients with coronary artery disease. Whether short-term statin therapy is associated with changes in the volume of EAT is currently unknown. A cohort of patients with atrial fibrillation who underwent pulmonary vein isolation were randomized to receive either 80 mg/day of atorvastatin (n = 38, 32 men, age 56 ± 11 years) or placebo (n = 41, 33 men, age 56 ± 10 years) for a 3-month period. EAT volume was assessed by cardiac computed tomography at baseline and at follow-up. Patients randomized to statin treatment exhibited a modest but significant decrease in median EAT volume (baseline vs follow-up: 92.3 cm3 [62.0 to 133.3] vs 86.9 cm3 [64.1 to 124.8], p 3 [55.5 to 110.9] vs 81.3 cm3 [57.1 to 110.5], p = NS). Changes in median systemic inflammatory markers and lipid profile were also seen with statin treatment: C-reactive protein (2.4 mg/L [0.7 to 3.7] vs 1.1 mg/L [0.5 to 2.7], p 2 [25 to 30] versus 27.6 kg/m2 [25.7 to 30.5], p = NS). No variations occurred in the placebo group. In conclusion, short-term intensive statin therapy significantly reduced the volume of EAT in patients with atrial fibrillation.

UR - http://www.scopus.com/inward/record.url?scp=84944355526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944355526&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2015.07.067

DO - 10.1016/j.amjcard.2015.07.067

M3 - Article

C2 - 26372211

AN - SCOPUS:84944355526

VL - 116

SP - 1443

EP - 1446

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 9

ER -