Effects of atorvastatin (80 mg) therapy on quantity of epicardial adipose tissue in patients undergoing pulmonary vein isolation for atrial fibrillation

Filip Soucek, Naima Covassin, Prachi Singh, Lukas Ruzek, Tomas Kara, Mahmoud Suleiman, Amir Lerman, Celeste Koestler, Paul Andrew Friedman, Francisco Lopez-Jimenez, Virend Somers

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Epicardial adipose tissue (EAT) has been recognized as a sensitive marker of cardiometabolic risk. Recent evidence suggests efficacy of long-term statin therapy in reducing EAT in patients with coronary artery disease. Whether short-term statin therapy is associated with changes in the volume of EAT is currently unknown. A cohort of patients with atrial fibrillation who underwent pulmonary vein isolation were randomized to receive either 80 mg/day of atorvastatin (n = 38, 32 men, age 56 ± 11 years) or placebo (n = 41, 33 men, age 56 ± 10 years) for a 3-month period. EAT volume was assessed by cardiac computed tomography at baseline and at follow-up. Patients randomized to statin treatment exhibited a modest but significant decrease in median EAT volume (baseline vs follow-up: 92.3 cm3 [62.0 to 133.3] vs 86.9 cm3 [64.1 to 124.8], p 3 [55.5 to 110.9] vs 81.3 cm3 [57.1 to 110.5], p = NS). Changes in median systemic inflammatory markers and lipid profile were also seen with statin treatment: C-reactive protein (2.4 mg/L [0.7 to 3.7] vs 1.1 mg/L [0.5 to 2.7], p 2 [25 to 30] versus 27.6 kg/m2 [25.7 to 30.5], p = NS). No variations occurred in the placebo group. In conclusion, short-term intensive statin therapy significantly reduced the volume of EAT in patients with atrial fibrillation.

Original languageEnglish (US)
Pages (from-to)1443-1446
Number of pages4
JournalAmerican Journal of Cardiology
Volume116
Issue number9
DOIs
StatePublished - Nov 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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