Effects of Aspirin Therapy on Ultrasound-Guided Renal Allograft Biopsy Bleeding Complications

Francis I. Baffour, LaTonya Hickson, Mark D Stegall, Patrick G. Dean, Tina M. Gunderson, Thomas D. Atwell, A. Nicholas Kurup, John J. Schmitz, Walter D. Park, Grant D. Schmit

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10 Scopus citations


Purpose: To determine if patient aspirin exposure and timing affect bleeding risk after renal allograft biopsy. Materials and Methods: Review of 6,700 renal allograft biopsies (in 2,362 unique patients) was performed. Median patient age was 53.0 years [interquartile range 43.0, 62.0]; 56.2% of patients were male. Of biopsies, 4,706 (70.2%) were performed in patients with no aspirin exposure within 10 days of biopsy; 664 (9.9%), were performed within 8-10 days of aspirin exposure; 855 (12.8%), within 4-7 days; and 475 (7.1%), within 0-3 days. Follow-up to 3 months after the procedure was completed in all patients. Biopsies were categorized as protocol or indication; 19.7% were indication biopsies. Bleeding complications were graded based on SIR criteria. Logistic regression models examined the association between aspirin use and bleeding events. Results: Rate [95% confidence interval] of major bleeding complications was 0.24% [0.14, 0.39], and rate of any bleeding complication was 0.66% [0.46, 0.90]. Bleeding events were significantly associated with patients undergoing indication biopsies compared with protocol biopsies (odds ratio [OR] 2.27, . P = .012). Patient factors associated with major bleeding complications in multivariate models included estimated glomerular filtration rate (OR 0.61, . P = .016) and platelet count (OR 0.64, . P = .033). Aspirin use was not significantly associated with increased risk of bleeding complication except for use of 325 mg of aspirin within 3 days of biopsy (any complication OR 3.87 [1.12, 13.4], . P = .032; major complication OR 6.30 [1.27, 31.3], . P = .024). Conclusions: Renal allograft biopsy bleeding complications are very rare, particularly for protocol biopsies. Use of 325 mg of aspirin within 3 days of renal allograft biopsy was associated with increased bleeding complications.

Original languageEnglish (US)
JournalJournal of Vascular and Interventional Radiology
StateAccepted/In press - Jul 19 2016
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Baffour, F. I., Hickson, L., Stegall, M. D., Dean, P. G., Gunderson, T. M., Atwell, T. D., Kurup, A. N., Schmitz, J. J., Park, W. D., & Schmit, G. D. (Accepted/In press). Effects of Aspirin Therapy on Ultrasound-Guided Renal Allograft Biopsy Bleeding Complications. Journal of Vascular and Interventional Radiology. https://doi.org/10.1016/j.jvir.2016.10.021