TY - JOUR
T1 - Effects of apolipoprotein E-ε4 and -ε2 in amnestic mild cognitive impairment and dementia in Shanghai
T2 - SCOBHI-P
AU - Borenstein, Amy R.
AU - Mortimer, James A.
AU - Ding, Ding
AU - Schellenberg, Gerard D.
AU - Decarli, Charles
AU - Zhao, Qianhua
AU - Copenhaver, Cathleen
AU - Guo, Qihao
AU - Chu, Shugang
AU - Galasko, Douglas
AU - Salmon, David P.
AU - Qi, Dai
AU - Wu, Yougui
AU - Petersen, Ronald
AU - Hong, Zhen
PY - 2010/5
Y1 - 2010/5
N2 - Objective: To determine apolipoprotein E (APOE)-ε4 and -ε2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China. Methods: A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods. Results: Among controls, frequencies were ε2, 0.11; ε3, 0.84; and ε4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any ε4 allele. The ε2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61). Conclusions: APOE-ε4 increases and -ε2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).
AB - Objective: To determine apolipoprotein E (APOE)-ε4 and -ε2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China. Methods: A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods. Results: Among controls, frequencies were ε2, 0.11; ε3, 0.84; and ε4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any ε4 allele. The ε2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61). Conclusions: APOE-ε4 increases and -ε2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).
KW - Apolipoprotein E
KW - China
KW - Dementia
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=77952131539&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952131539&partnerID=8YFLogxK
U2 - 10.1177/1533317509357736
DO - 10.1177/1533317509357736
M3 - Article
C2 - 20142627
AN - SCOPUS:77952131539
SN - 1533-3175
VL - 25
SP - 233
EP - 238
JO - American Journal of Alzheimer's Disease and Other Dementias
JF - American Journal of Alzheimer's Disease and Other Dementias
IS - 3
ER -