Effects of an osmotically active agent on colonic transit

S. M. Skoog, Adil Eddie Bharucha, Michael Camilleri, D. D. Burton, A. R. Zinsmeister

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

It is unknown if sorbitol, a widely used laxative agent, accelerates colonic transit, and if these effects are modified by concomitant meal ingestion. Colonic transit was assessed by 111In scintigraphy in 40 healthy subjects. After a 24-h scan, subjects received sorbitol (30 mL of 70% solution) or dextrose (30 mL of 70% solution), administered with or without a meal. Colonic transit, breath hydrogen excretion, and symptom scores were recorded for 4 h thereafter. VAS scores for flatulence, but not other symptoms increased (P = 0.004) by 13.1 ± 6.3 mm (mean ± SEM) on a 100 mm scale after sorbitol alone or sorbitol with a meal (by 18.9 ± 7.2 mm), but not after dextrose. After adjusting for GC24, sorbitol accelerated (P < 0.001) colonic transit (GC28 = 3.0 ± 0.3) compared with dextrose (GC28 = 2.2 ± 0.2), regardless of meal ingestion. Breath hydrogen excretion was correlated with the change in colonic transit (r = 0.52, P < 0.01) and with flatulence (r = 0.45, P = 0.003) after sugar ingestion. In healthy subjects, sorbitol accelerated colonic transit and increased flatulence but not other symptoms within 4 h, regardless of meal intake.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalNeurogastroenterology and Motility
Volume18
Issue number4
DOIs
StatePublished - Apr 2006

Fingerprint

Sorbitol
Meals
Flatulence
Eating
Glucose
Hydrogen
Healthy Volunteers
Laxatives
Radionuclide Imaging

Keywords

  • Breath hydrogen
  • Colon transit
  • Laxatives
  • Osmotic
  • Symptoms

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Neuroscience(all)

Cite this

Effects of an osmotically active agent on colonic transit. / Skoog, S. M.; Bharucha, Adil Eddie; Camilleri, Michael; Burton, D. D.; Zinsmeister, A. R.

In: Neurogastroenterology and Motility, Vol. 18, No. 4, 04.2006, p. 300-306.

Research output: Contribution to journalArticle

Skoog, S. M. ; Bharucha, Adil Eddie ; Camilleri, Michael ; Burton, D. D. ; Zinsmeister, A. R. / Effects of an osmotically active agent on colonic transit. In: Neurogastroenterology and Motility. 2006 ; Vol. 18, No. 4. pp. 300-306.
@article{b06150d795ee44caa29bb600fd25caaa,
title = "Effects of an osmotically active agent on colonic transit",
abstract = "It is unknown if sorbitol, a widely used laxative agent, accelerates colonic transit, and if these effects are modified by concomitant meal ingestion. Colonic transit was assessed by 111In scintigraphy in 40 healthy subjects. After a 24-h scan, subjects received sorbitol (30 mL of 70{\%} solution) or dextrose (30 mL of 70{\%} solution), administered with or without a meal. Colonic transit, breath hydrogen excretion, and symptom scores were recorded for 4 h thereafter. VAS scores for flatulence, but not other symptoms increased (P = 0.004) by 13.1 ± 6.3 mm (mean ± SEM) on a 100 mm scale after sorbitol alone or sorbitol with a meal (by 18.9 ± 7.2 mm), but not after dextrose. After adjusting for GC24, sorbitol accelerated (P < 0.001) colonic transit (GC28 = 3.0 ± 0.3) compared with dextrose (GC28 = 2.2 ± 0.2), regardless of meal ingestion. Breath hydrogen excretion was correlated with the change in colonic transit (r = 0.52, P < 0.01) and with flatulence (r = 0.45, P = 0.003) after sugar ingestion. In healthy subjects, sorbitol accelerated colonic transit and increased flatulence but not other symptoms within 4 h, regardless of meal intake.",
keywords = "Breath hydrogen, Colon transit, Laxatives, Osmotic, Symptoms",
author = "Skoog, {S. M.} and Bharucha, {Adil Eddie} and Michael Camilleri and Burton, {D. D.} and Zinsmeister, {A. R.}",
year = "2006",
month = "4",
doi = "10.1111/j.1365-2982.2006.00757.x",
language = "English (US)",
volume = "18",
pages = "300--306",
journal = "Neurogastroenterology and Motility",
issn = "1350-1925",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Effects of an osmotically active agent on colonic transit

AU - Skoog, S. M.

AU - Bharucha, Adil Eddie

AU - Camilleri, Michael

AU - Burton, D. D.

AU - Zinsmeister, A. R.

PY - 2006/4

Y1 - 2006/4

N2 - It is unknown if sorbitol, a widely used laxative agent, accelerates colonic transit, and if these effects are modified by concomitant meal ingestion. Colonic transit was assessed by 111In scintigraphy in 40 healthy subjects. After a 24-h scan, subjects received sorbitol (30 mL of 70% solution) or dextrose (30 mL of 70% solution), administered with or without a meal. Colonic transit, breath hydrogen excretion, and symptom scores were recorded for 4 h thereafter. VAS scores for flatulence, but not other symptoms increased (P = 0.004) by 13.1 ± 6.3 mm (mean ± SEM) on a 100 mm scale after sorbitol alone or sorbitol with a meal (by 18.9 ± 7.2 mm), but not after dextrose. After adjusting for GC24, sorbitol accelerated (P < 0.001) colonic transit (GC28 = 3.0 ± 0.3) compared with dextrose (GC28 = 2.2 ± 0.2), regardless of meal ingestion. Breath hydrogen excretion was correlated with the change in colonic transit (r = 0.52, P < 0.01) and with flatulence (r = 0.45, P = 0.003) after sugar ingestion. In healthy subjects, sorbitol accelerated colonic transit and increased flatulence but not other symptoms within 4 h, regardless of meal intake.

AB - It is unknown if sorbitol, a widely used laxative agent, accelerates colonic transit, and if these effects are modified by concomitant meal ingestion. Colonic transit was assessed by 111In scintigraphy in 40 healthy subjects. After a 24-h scan, subjects received sorbitol (30 mL of 70% solution) or dextrose (30 mL of 70% solution), administered with or without a meal. Colonic transit, breath hydrogen excretion, and symptom scores were recorded for 4 h thereafter. VAS scores for flatulence, but not other symptoms increased (P = 0.004) by 13.1 ± 6.3 mm (mean ± SEM) on a 100 mm scale after sorbitol alone or sorbitol with a meal (by 18.9 ± 7.2 mm), but not after dextrose. After adjusting for GC24, sorbitol accelerated (P < 0.001) colonic transit (GC28 = 3.0 ± 0.3) compared with dextrose (GC28 = 2.2 ± 0.2), regardless of meal ingestion. Breath hydrogen excretion was correlated with the change in colonic transit (r = 0.52, P < 0.01) and with flatulence (r = 0.45, P = 0.003) after sugar ingestion. In healthy subjects, sorbitol accelerated colonic transit and increased flatulence but not other symptoms within 4 h, regardless of meal intake.

KW - Breath hydrogen

KW - Colon transit

KW - Laxatives

KW - Osmotic

KW - Symptoms

UR - http://www.scopus.com/inward/record.url?scp=33645035079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645035079&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2982.2006.00757.x

DO - 10.1111/j.1365-2982.2006.00757.x

M3 - Article

C2 - 16553585

AN - SCOPUS:33645035079

VL - 18

SP - 300

EP - 306

JO - Neurogastroenterology and Motility

JF - Neurogastroenterology and Motility

SN - 1350-1925

IS - 4

ER -