Effects of aliphatic diamines on rat liver ornithine decarboxylase activity

A. E. Pegg, Cheryl A Conover, A. Wrona

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Rat liver ornithine decarboxylase activity was decreased by administration of putrescine (1,4-diaminobutane) or other diamines, including 1,3-diaminopropane, 1,5-diaminopentane and 1,6-diaminohexane. This effect was seen in control rats and in rats in which hepatic ornithine decarboxylase activity had been increased by administration of growth hormone (somatotropin) or thioacetamide. Loss of activity was not dependent on the conversion of putrescine into polyamines and was short-lived. Within 6h after intraperitoneal administration of 0.8 mmol/kg body wt., ornithine decarboxylase activity had returned to normal values. This return correlated with the rapid loss of the diamines from the liver, and the decrease in activity could be slightly prolonged by treatment with aminoguanidine, a diamine oxidase inhibitor. A decrease in ornithine decarboxylase activity by these diamines was accompanied by the accumulation in the liver of a non-diffusible inhibitor that decreased the activity of a purified ornithine decarboxylase preparation. The possibility that administration of non-physiological diamines that are not converted into polyamines might be useful for the inhibition of polyamine synthesis is discussed.

Original languageEnglish (US)
Pages (from-to)651-660
Number of pages10
JournalBiochemical Journal
Volume170
Issue number3
StatePublished - 1978
Externally publishedYes

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Ornithine Decarboxylase
Diamines
Liver
Rats
Putrescine
Polyamines
1,6-diaminohexane
Growth Hormone
Rat control
Thioacetamide
Amine Oxidase (Copper-Containing)
Reference Values

ASJC Scopus subject areas

  • Biochemistry

Cite this

Effects of aliphatic diamines on rat liver ornithine decarboxylase activity. / Pegg, A. E.; Conover, Cheryl A; Wrona, A.

In: Biochemical Journal, Vol. 170, No. 3, 1978, p. 651-660.

Research output: Contribution to journalArticle

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