Effects of Age on Left Ventricular Dimensions and Filling Dynamics in 117 Normal Persons

To determine standard left ventricular Doppler measurements in a large reference group of various ages to reflect the senescence process. We prospectively studied the influence of aging on left ventricular diastolic filling by performing Doppler echocardiography in 117 normal healthy volunteers. Transthoracic pulsed-wave Doppler echocardiographic studies of pulmonary venous flow and left ventricular inflow were done in the 53 male and 64 female study subjects. For analysis, the study subjects were arbitrarily classified into two groups: those younger than 50 years of age (group 1; N = 61) and those 50 years old or older (group 2; N = 56). A striking difference was found in pulmonary venous flow and left ventricular inflow between group 1 and group 2 subjects. Group 2 had increased pulmonary venous peak systolic flow velocity (71 ± 9 versus 48 ± 9 cm/s), decreased peak diastolic flow velocity (38 ± 9 versus 50 ± 10 cm/s), increased peak atrial reversal flow velocity (23 ± 4 versus 19 ± 4 cm/s), and increased percentage of forward flow in systole (65 ± 7 versus 55 ± 8%) in comparison with group 1. In group 2, peak early filling velocity (62 ± 14 versus 72 ± 14 cm/s) and ratio of early filling to atrial filling (1.1 ± 0.3 versus 1.9 ± 0.6) were lower and peak atrial filling velocity (59 ± 14 versus 40 ± 10 cm/s) was higher than in group 1. Deceleration time (210 ± 36 versus 179 ± 20 ms) and isovolumic relaxation time (90 ± 17 versus 76 ± 11 ms) were prolonged in group 2 in comparison with group 1. This study confirms the major influence of the aging process on left ventricular diastolic function in a large series of normal subjects. This physiologic factor should be considered in Doppler assessment of left ventricular diastolic filling in future studies.