Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines

Xinghua Wang; Anthony Pham; Lu Kang; Sierra A. Walker; Irina Davidovich; Dalila Iannotta; Sarvam P. Terkonda; Shane Shapiro; Yeshayahu Talmon; Si Pham; Joy Wolfram

doi:10.3390/pharmaceutics14010016

Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines

Xinghua Wang, Anthony Pham, Lu Kang, Sierra A. Walker, Irina Davidovich, Dalila Iannotta, Sarvam P. Terkonda, Shane Shapiro, Yeshayahu Talmon, Si Pham, Joy Wolfram

Research output: Contribution to journal › Article › peer-review

Abstract

Extracellular vesicles (EVs) are cell-released nanoparticles that transfer biomolecular content between cells. Among EV-associated biomolecules, microRNAs (miRNAs/miRs) represent one of the most important modulators of signaling pathways in recipient cells. Previous studies have shown that EVs from adipose-derived mesenchymal stromal cells (MSCs) and adipose tissue modulate inflammatory pathways in macrophages. In this study, the effects of miRNAs that are abundant in adipose tissue EVs and other biogenic nanoparticles (BiNPs) were assessed in terms of altering Toll-like receptor 4 (TLR4)-induced cytokines. TLR-4 signaling in macrophages is often triggered by pathogen or damage-induced inflammation and is associated with several diseases. This study demonstrates that miR-451a, which is abundant in adipose tissue BiNPs, suppresses pro-inflammatory cytokines and increases anti-inflammatory cytokines associated with the TLR4 pathway. Therefore, miR-451a may be partially responsible for immunomodulatory effects of adipose tissue-derived BiNPs.

Original language	English (US)
Article number	16
Journal	Pharmaceutics
Volume	14
Issue number	1
DOIs	https://doi.org/10.3390/pharmaceutics14010016
State	Published - Jan 2022

Keywords

Exosome
Extracellular vesicle
MicroRNA
Microvesicle
Toll-like receptor 4

ASJC Scopus subject areas

Pharmaceutical Science

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10.3390/pharmaceutics14010016

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title = "Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines",

abstract = "Extracellular vesicles (EVs) are cell-released nanoparticles that transfer biomolecular content between cells. Among EV-associated biomolecules, microRNAs (miRNAs/miRs) represent one of the most important modulators of signaling pathways in recipient cells. Previous studies have shown that EVs from adipose-derived mesenchymal stromal cells (MSCs) and adipose tissue modulate inflammatory pathways in macrophages. In this study, the effects of miRNAs that are abundant in adipose tissue EVs and other biogenic nanoparticles (BiNPs) were assessed in terms of altering Toll-like receptor 4 (TLR4)-induced cytokines. TLR-4 signaling in macrophages is often triggered by pathogen or damage-induced inflammation and is associated with several diseases. This study demonstrates that miR-451a, which is abundant in adipose tissue BiNPs, suppresses pro-inflammatory cytokines and increases anti-inflammatory cytokines associated with the TLR4 pathway. Therefore, miR-451a may be partially responsible for immunomodulatory effects of adipose tissue-derived BiNPs.",

keywords = "Exosome, Extracellular vesicle, MicroRNA, Microvesicle, Toll-like receptor 4",

author = "Xinghua Wang and Anthony Pham and Lu Kang and Walker, {Sierra A.} and Irina Davidovich and Dalila Iannotta and Terkonda, {Sarvam P.} and Shane Shapiro and Yeshayahu Talmon and Si Pham and Joy Wolfram",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jan,

doi = "10.3390/pharmaceutics14010016",

language = "English (US)",

volume = "14",

journal = "Pharmaceutics",

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T1 - Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines

AU - Wang, Xinghua

AU - Pham, Anthony

AU - Kang, Lu

AU - Walker, Sierra A.

AU - Davidovich, Irina

AU - Iannotta, Dalila

AU - Terkonda, Sarvam P.

AU - Shapiro, Shane

AU - Talmon, Yeshayahu

AU - Pham, Si

AU - Wolfram, Joy

PY - 2022/1

Y1 - 2022/1

N2 - Extracellular vesicles (EVs) are cell-released nanoparticles that transfer biomolecular content between cells. Among EV-associated biomolecules, microRNAs (miRNAs/miRs) represent one of the most important modulators of signaling pathways in recipient cells. Previous studies have shown that EVs from adipose-derived mesenchymal stromal cells (MSCs) and adipose tissue modulate inflammatory pathways in macrophages. In this study, the effects of miRNAs that are abundant in adipose tissue EVs and other biogenic nanoparticles (BiNPs) were assessed in terms of altering Toll-like receptor 4 (TLR4)-induced cytokines. TLR-4 signaling in macrophages is often triggered by pathogen or damage-induced inflammation and is associated with several diseases. This study demonstrates that miR-451a, which is abundant in adipose tissue BiNPs, suppresses pro-inflammatory cytokines and increases anti-inflammatory cytokines associated with the TLR4 pathway. Therefore, miR-451a may be partially responsible for immunomodulatory effects of adipose tissue-derived BiNPs.

AB - Extracellular vesicles (EVs) are cell-released nanoparticles that transfer biomolecular content between cells. Among EV-associated biomolecules, microRNAs (miRNAs/miRs) represent one of the most important modulators of signaling pathways in recipient cells. Previous studies have shown that EVs from adipose-derived mesenchymal stromal cells (MSCs) and adipose tissue modulate inflammatory pathways in macrophages. In this study, the effects of miRNAs that are abundant in adipose tissue EVs and other biogenic nanoparticles (BiNPs) were assessed in terms of altering Toll-like receptor 4 (TLR4)-induced cytokines. TLR-4 signaling in macrophages is often triggered by pathogen or damage-induced inflammation and is associated with several diseases. This study demonstrates that miR-451a, which is abundant in adipose tissue BiNPs, suppresses pro-inflammatory cytokines and increases anti-inflammatory cytokines associated with the TLR4 pathway. Therefore, miR-451a may be partially responsible for immunomodulatory effects of adipose tissue-derived BiNPs.

KW - Exosome

KW - Extracellular vesicle

KW - MicroRNA

KW - Microvesicle

KW - Toll-like receptor 4

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DO - 10.3390/pharmaceutics14010016

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Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines

Abstract

Keywords

ASJC Scopus subject areas

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