Effects of acute bile acid administration on biliary lipid secretion in healthy volunteers

C. Sama, Nicholas F La Russo, V. Lopez del Pino, J. L. Thistle

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We investigated the effects of acute bile acid administration on biliary lipid secretion in 8 healthy subjects by a perfusion technique that employed an orojejunal tube with an occlusive balloon. In seventeen 8-h experiments, we measured bile acid, cholesterol, and phospholipid outputs before, during, and after rapid replacement of the bile acid pool with chenodeoxycholic, ursodeoxycholic, or cholic acid. Cholesterol and phospholipid outputs were linearly coupled to bile acid output before and after endogenous bile acid pool replacement. Cholesterol secretion was significantly lower after replacement with ursodeoxycholic acid than during the prereplacement phase or after replacement with chenodeoxycholic or cholic acid. Replacement with chenodeoxycholic acid had no significant effect on cholesterol or phospholipid secretion, whereas replacement with either ursodeoxycholic or cholic acids significantly reduced phospholipid output. We conclude that in healthy volunteers, acute administration of different bile acids specifically alters biliary lipid secretion. The rapidity of the changes in cholesterol and phospholipid secretion suggests that these effects are secondary to alterations in the secretory coupling of biliary lipids rather than to changes in their synthesis or absorption.

Original languageEnglish (US)
Pages (from-to)515-525
Number of pages11
JournalGastroenterology
Volume82
Issue number3
StatePublished - 1982

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Bile Acids and Salts
Healthy Volunteers
Phospholipids
Lipids
Cholesterol
Cholic Acid
Cholic Acids
Chenodeoxycholic Acid
Ursodeoxycholic Acid
Perfusion

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effects of acute bile acid administration on biliary lipid secretion in healthy volunteers. / Sama, C.; La Russo, Nicholas F; Lopez del Pino, V.; Thistle, J. L.

In: Gastroenterology, Vol. 82, No. 3, 1982, p. 515-525.

Research output: Contribution to journalArticle

Sama, C, La Russo, NF, Lopez del Pino, V & Thistle, JL 1982, 'Effects of acute bile acid administration on biliary lipid secretion in healthy volunteers', Gastroenterology, vol. 82, no. 3, pp. 515-525.
Sama, C. ; La Russo, Nicholas F ; Lopez del Pino, V. ; Thistle, J. L. / Effects of acute bile acid administration on biliary lipid secretion in healthy volunteers. In: Gastroenterology. 1982 ; Vol. 82, No. 3. pp. 515-525.
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