TY - JOUR
T1 - Effects of Acute Bile Acid Administration on Biliary Lipid Secretion in Healthy Volunteers
AU - Sama, Claudia
AU - LaRusso, Nicholas F.
AU - Lopez del Pino, Victor
AU - Thistle, Johnson L.
PY - 1982
Y1 - 1982
N2 - We investigated the effects of acute bile acid administration on biliary lipid secretion in 8 healthy subjects by a perfusion technique that employed an orojejunal tube with an occlusive balloon. In seventeen 8-h experiments, we measured bile acid, cholesterol, and phospholipid outputs before, during, and after rapid replacement of the bile acid pool with chenodeoxycholic, ursodeoxycholic, or cholic acid. Cholesterol and phospholipid outputs were linearly coupled to bile acid output before and after endogenous bile acid pool replacement. Cholesterol secretion was significantly lower after replacement with ursodeoxycholic acid than during the prereplacement phase or after replacement with chenodeoxycholic or cholic acid. Replacement with chenode oxycholic acid had no significant effect on cholesterol or phospholipid secretion, whereas replacement with either ursodeoxycholic or cholic acids significantly reduced phospholipid output. We conclude that in healthy volunteers, acute administration of different bile acids specifically alters biliary lipid secretion. The rapidity of the changes in cholesterol and phospholipid secretion suggests that these effects are secondary to alterations in the secretory coupling of biliary lipids rather than to changes in their synthesis or absorption.
AB - We investigated the effects of acute bile acid administration on biliary lipid secretion in 8 healthy subjects by a perfusion technique that employed an orojejunal tube with an occlusive balloon. In seventeen 8-h experiments, we measured bile acid, cholesterol, and phospholipid outputs before, during, and after rapid replacement of the bile acid pool with chenodeoxycholic, ursodeoxycholic, or cholic acid. Cholesterol and phospholipid outputs were linearly coupled to bile acid output before and after endogenous bile acid pool replacement. Cholesterol secretion was significantly lower after replacement with ursodeoxycholic acid than during the prereplacement phase or after replacement with chenodeoxycholic or cholic acid. Replacement with chenode oxycholic acid had no significant effect on cholesterol or phospholipid secretion, whereas replacement with either ursodeoxycholic or cholic acids significantly reduced phospholipid output. We conclude that in healthy volunteers, acute administration of different bile acids specifically alters biliary lipid secretion. The rapidity of the changes in cholesterol and phospholipid secretion suggests that these effects are secondary to alterations in the secretory coupling of biliary lipids rather than to changes in their synthesis or absorption.
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U2 - 10.1016/S0016-5085(82)80401-0
DO - 10.1016/S0016-5085(82)80401-0
M3 - Article
C2 - 7054046
AN - SCOPUS:0020035635
SN - 0016-5085
VL - 82
SP - 515
EP - 525
JO - Gastroenterology
JF - Gastroenterology
IS - 3
ER -