Effects of acute and long-term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension

Dagmara Hering, Wieslawa Kucharska, Tomas Kara, Virend Somers, Gianfranco Parati, Krzysztof Narkiewicz

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: Acute slow breathing (SLOWB) affects sympathetic cardiovascular regulation, but its long-term effects are unknown. Using device-guided breathing we explored short-term and long-term SLOWB effects on blood pressure (BP), heart rate (HR) and muscle sympathetic nerve activity (MSNA) in essential hypertension. Methods: We measured BP, HR and MSNA in 10 hypertensive individuals at rest, during laboratory stressors, before and after acute SLOWB, and 8 weeks after SLOWB exercise. Twelve matched hypertensive controls underwent a similar protocol excluding SLOWB intervention. Office and 24-h BP were obtained at baseline and at follow-up. Results: Acute SLOWB had no influence on BP, HR, but decreased MSNA (P<0.01). BP, HR, MSNA responses to handgrip were comparable before and after acute SLOWB. Acute SLOWB tended to reduce SBP (P=0.09), HR (P=0.08), but not MSNA (P=0.20) responses to mental stress. Long-term SLOWB decreased office SBP (P<0.001), DBP (P<0.01), HR (P=0.004), but not 24-h BP. Resting MSNA was unchanged after long-term SLOWB (P=0.68). Long-term SLOWB did not influence BP, HR or MSNA responses to handgrip and cold pressor, but reduced SBP (P=0.03), HR (P=0.03) responses to mental stress without MSNA changes. In controls BP, HR, MSNA responses to laboratory stressors remained unchanged at baseline and at follow-up. Conclusion: In essential hypertension, MSNA is reduced during acute SLOWB, but remains unaltered following long-term SLOWB. Long-term SLOWB reduces office, but not ambulatory BP and HR. SLOWB attenuates cardiovascular response to mental stress, but not physical stressors. These findings may be indicative of beneficial SLOWB effects on stress reduction in essential hypertension.

Original languageEnglish (US)
Pages (from-to)739-746
Number of pages8
JournalJournal of Hypertension
Volume31
Issue number4
DOIs
StatePublished - Apr 2013

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Breathing Exercises
Respiration
Hypertension
Muscles
Heart Rate
Blood Pressure
Myocardium

Keywords

  • essential hypertension
  • laboratory stressors
  • slow breathing
  • sympathetic activity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of acute and long-term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension. / Hering, Dagmara; Kucharska, Wieslawa; Kara, Tomas; Somers, Virend; Parati, Gianfranco; Narkiewicz, Krzysztof.

In: Journal of Hypertension, Vol. 31, No. 4, 04.2013, p. 739-746.

Research output: Contribution to journalArticle

Hering, Dagmara ; Kucharska, Wieslawa ; Kara, Tomas ; Somers, Virend ; Parati, Gianfranco ; Narkiewicz, Krzysztof. / Effects of acute and long-term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension. In: Journal of Hypertension. 2013 ; Vol. 31, No. 4. pp. 739-746.
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AU - Hering, Dagmara

AU - Kucharska, Wieslawa

AU - Kara, Tomas

AU - Somers, Virend

AU - Parati, Gianfranco

AU - Narkiewicz, Krzysztof

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N2 - Objective: Acute slow breathing (SLOWB) affects sympathetic cardiovascular regulation, but its long-term effects are unknown. Using device-guided breathing we explored short-term and long-term SLOWB effects on blood pressure (BP), heart rate (HR) and muscle sympathetic nerve activity (MSNA) in essential hypertension. Methods: We measured BP, HR and MSNA in 10 hypertensive individuals at rest, during laboratory stressors, before and after acute SLOWB, and 8 weeks after SLOWB exercise. Twelve matched hypertensive controls underwent a similar protocol excluding SLOWB intervention. Office and 24-h BP were obtained at baseline and at follow-up. Results: Acute SLOWB had no influence on BP, HR, but decreased MSNA (P<0.01). BP, HR, MSNA responses to handgrip were comparable before and after acute SLOWB. Acute SLOWB tended to reduce SBP (P=0.09), HR (P=0.08), but not MSNA (P=0.20) responses to mental stress. Long-term SLOWB decreased office SBP (P<0.001), DBP (P<0.01), HR (P=0.004), but not 24-h BP. Resting MSNA was unchanged after long-term SLOWB (P=0.68). Long-term SLOWB did not influence BP, HR or MSNA responses to handgrip and cold pressor, but reduced SBP (P=0.03), HR (P=0.03) responses to mental stress without MSNA changes. In controls BP, HR, MSNA responses to laboratory stressors remained unchanged at baseline and at follow-up. Conclusion: In essential hypertension, MSNA is reduced during acute SLOWB, but remains unaltered following long-term SLOWB. Long-term SLOWB reduces office, but not ambulatory BP and HR. SLOWB attenuates cardiovascular response to mental stress, but not physical stressors. These findings may be indicative of beneficial SLOWB effects on stress reduction in essential hypertension.

AB - Objective: Acute slow breathing (SLOWB) affects sympathetic cardiovascular regulation, but its long-term effects are unknown. Using device-guided breathing we explored short-term and long-term SLOWB effects on blood pressure (BP), heart rate (HR) and muscle sympathetic nerve activity (MSNA) in essential hypertension. Methods: We measured BP, HR and MSNA in 10 hypertensive individuals at rest, during laboratory stressors, before and after acute SLOWB, and 8 weeks after SLOWB exercise. Twelve matched hypertensive controls underwent a similar protocol excluding SLOWB intervention. Office and 24-h BP were obtained at baseline and at follow-up. Results: Acute SLOWB had no influence on BP, HR, but decreased MSNA (P<0.01). BP, HR, MSNA responses to handgrip were comparable before and after acute SLOWB. Acute SLOWB tended to reduce SBP (P=0.09), HR (P=0.08), but not MSNA (P=0.20) responses to mental stress. Long-term SLOWB decreased office SBP (P<0.001), DBP (P<0.01), HR (P=0.004), but not 24-h BP. Resting MSNA was unchanged after long-term SLOWB (P=0.68). Long-term SLOWB did not influence BP, HR or MSNA responses to handgrip and cold pressor, but reduced SBP (P=0.03), HR (P=0.03) responses to mental stress without MSNA changes. In controls BP, HR, MSNA responses to laboratory stressors remained unchanged at baseline and at follow-up. Conclusion: In essential hypertension, MSNA is reduced during acute SLOWB, but remains unaltered following long-term SLOWB. Long-term SLOWB reduces office, but not ambulatory BP and HR. SLOWB attenuates cardiovascular response to mental stress, but not physical stressors. These findings may be indicative of beneficial SLOWB effects on stress reduction in essential hypertension.

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