Effects of a κ-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans

Silvia Delgado-Aros, Heather J. Chial, Michael Camilleri, Lawrence A. Szarka, Frank T. Weber, Jutta Jacob, Irene Ferber, Sanna McKinzie, Duane D. Burton, Alan R. Zinsmeister

Research output: Contribution to journalArticle

95 Scopus citations

Abstract

To compare the effects of the κ-opioid agonist asimadoline and placebo on visceral sensation and gastrointestinal (GI) motor functions in humans, 91 healthy participants were randomized in a double-blind fashion to 0.15, 0.5, or 1.5 mg of asimadoline or placebo orally twice a day for 9 days. We assessed satiation (nutrient drink test), colonic compliance, tone, perception of colonic distension (barostat), and whole gut transit (scintigraphy). Treatment effect was assessed by analysis of covariance. Asimadoline increased nutrient drink intake (P = 0.03). Asimadoline decreased colonic tone during fasting (P = 0.03) without affecting postprandial colonic contraction, compliance, or transit. Gas scores in response to colonic distension were decreased with 0.5 mg of asimadoline at low levels (8 mmHg above operating pressure) of distension (P = 0.04) but not at higher levels of distension. Asimadoline at 1.5 mg increased gas scores at 16 mmHg of distension (P = 0.03) and pain scores at distensions of 8 and 16 mmHg (P = 0.003 and 0.03, respectively) but not at higher levels of distension. Further studies of this compound in diseases with altered satiation or visceral sensation are warranted.

Original languageEnglish (US)
Pages (from-to)G558-G566
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume284
Issue number4 47-4
StatePublished - Apr 1 2003

Keywords

  • Barostat
  • Colon
  • Sensation
  • Stomach
  • Visceral

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)

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    Delgado-Aros, S., Chial, H. J., Camilleri, M., Szarka, L. A., Weber, F. T., Jacob, J., Ferber, I., McKinzie, S., Burton, D. D., & Zinsmeister, A. R. (2003). Effects of a κ-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans. American Journal of Physiology - Gastrointestinal and Liver Physiology, 284(4 47-4), G558-G566.