Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate

H. S A Sherratt, S. J. Gatley, Timothy R DeGrado, C. K. Ng, J. E. Holden

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Long-chain fatty acid oxidation by the isolated perfused rat heart was assayed by external counting using [125I]16-iodohexadecanoic acid as substrate after administration of the hypoketonemic and hypoglycemic compound 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate to rats. Glucose metabolism was also assessed by measuring release of tritium from [2-T]glucose. The oxidation of long chain fatty acids was virtually suppressed in hearts from fed or starved rats given 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate while glucose utilization was increased 2-2.5 fold.

Original languageEnglish (US)
Pages (from-to)653-657
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume117
Issue number3
DOIs
StatePublished - Dec 28 1983
Externally publishedYes

Fingerprint

Ethylene Oxide
Metabolism
Iodine
Rats
Fatty Acids
Glucose
Oxidation
Tritium
Hypoglycemic Agents
Substrates

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

@article{8a2a76f5bbc74aeca04cb42dddea3646,
title = "Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate",
abstract = "Long-chain fatty acid oxidation by the isolated perfused rat heart was assayed by external counting using [125I]16-iodohexadecanoic acid as substrate after administration of the hypoketonemic and hypoglycemic compound 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate to rats. Glucose metabolism was also assessed by measuring release of tritium from [2-T]glucose. The oxidation of long chain fatty acids was virtually suppressed in hearts from fed or starved rats given 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate while glucose utilization was increased 2-2.5 fold.",
author = "Sherratt, {H. S A} and Gatley, {S. J.} and DeGrado, {Timothy R} and Ng, {C. K.} and Holden, {J. E.}",
year = "1983",
month = "12",
day = "28",
doi = "10.1016/0006-291X(83)91646-7",
language = "English (US)",
volume = "117",
pages = "653--657",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate

AU - Sherratt, H. S A

AU - Gatley, S. J.

AU - DeGrado, Timothy R

AU - Ng, C. K.

AU - Holden, J. E.

PY - 1983/12/28

Y1 - 1983/12/28

N2 - Long-chain fatty acid oxidation by the isolated perfused rat heart was assayed by external counting using [125I]16-iodohexadecanoic acid as substrate after administration of the hypoketonemic and hypoglycemic compound 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate to rats. Glucose metabolism was also assessed by measuring release of tritium from [2-T]glucose. The oxidation of long chain fatty acids was virtually suppressed in hearts from fed or starved rats given 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate while glucose utilization was increased 2-2.5 fold.

AB - Long-chain fatty acid oxidation by the isolated perfused rat heart was assayed by external counting using [125I]16-iodohexadecanoic acid as substrate after administration of the hypoketonemic and hypoglycemic compound 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate to rats. Glucose metabolism was also assessed by measuring release of tritium from [2-T]glucose. The oxidation of long chain fatty acids was virtually suppressed in hearts from fed or starved rats given 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate while glucose utilization was increased 2-2.5 fold.

UR - http://www.scopus.com/inward/record.url?scp=0021051418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021051418&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(83)91646-7

DO - 10.1016/0006-291X(83)91646-7

M3 - Article

C2 - 6667268

AN - SCOPUS:0021051418

VL - 117

SP - 653

EP - 657

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 3

ER -