Effects of 2-deoxy-D-glucose on human monocyte metabolism and function

N. E. Kay, T. F. Bumol, S. D. Douglas

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A glucose analogue, 2-deoxy-D-glucose (2-DOG) was utilized to evaluate relationships between monocyte metabolism and cellular function. Chemotaxis, spreading and phagocytosis were decreased in 2-DOG-exposed monocytes. Addition of glucose restored some of these functions towards normal levels. Adenosine triphosphate production did not correlate with restoration of cellular functions. Decreased incorporation of radiolabeled mannose into acid insoluble material was demonstrated in 2-DOG-exposed monocytes. The biosynthesis of plasma membrane components may be altered in 2-DOG-treated monocytes and may lead to changes in cell membrane-related events.

Original languageEnglish (US)
Pages (from-to)367-379
Number of pages13
JournalRES Journal of the Reticuloendothelial Society
Volume28
Issue number4
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Hematology

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