Effects of 1α,25(OH)2D3 and its analogs on dendritic cell function

Matthew D. Griffin, Rajiv Kumar

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) and non-calcemic vitamin D analogs induce a persistent state of immaturity in dendritic cells both in vitro and in vivo. These effects are transcriptional in nature, involve alterations in surface ligands as well as cytokine synthesis and release, and are dependent upon the presence of the vitamin D receptor. The vitamin D endocrine system could also play a role in altering immune function in normal physiological conditions. Distinct differences exist in lymph node dendritic cells of vitamin D receptor null mutant mice when compared to normal mice.

Original languageEnglish (US)
Pages (from-to)323-326
Number of pages4
JournalJournal of Cellular Biochemistry
Volume88
Issue number2
DOIs
StatePublished - Feb 1 2003

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Calcitriol Receptors
Vitamin D
Dendritic Cells
Endocrine System
Calcitriol
Lymph Nodes
Cytokines
Ligands
In Vitro Techniques

Keywords

  • 1 α,25-Dihydroxyvitamin D
  • Dendritic cells
  • Immune function

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Effects of 1α,25(OH)2D3 and its analogs on dendritic cell function. / Griffin, Matthew D.; Kumar, Rajiv.

In: Journal of Cellular Biochemistry, Vol. 88, No. 2, 01.02.2003, p. 323-326.

Research output: Contribution to journalArticle

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