Effects of 1α,25(OH)2D3 and its analogs on dendritic cell function

Matthew D. Griffin, Rajiv Kumar

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

1α,25-Dihydroxyvitamin D3 (1α,25(OH)2D3) and non-calcemic vitamin D analogs induce a persistent state of immaturity in dendritic cells both in vitro and in vivo. These effects are transcriptional in nature, involve alterations in surface ligands as well as cytokine synthesis and release, and are dependent upon the presence of the vitamin D receptor. The vitamin D endocrine system could also play a role in altering immune function in normal physiological conditions. Distinct differences exist in lymph node dendritic cells of vitamin D receptor null mutant mice when compared to normal mice.

Original languageEnglish (US)
Pages (from-to)323-326
Number of pages4
JournalJournal of cellular biochemistry
Volume88
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • 1 α,25-Dihydroxyvitamin D
  • Dendritic cells
  • Immune function

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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