Effectiveness of prophylactic mastectomy in the prevention of breast tumors in C3H mice

Heidi Nelson, Stephen H. Miller, David Buck, Robert J. Demuth, William S. Fletcher, Peter Buehler

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effectiveness of prophylactic mastectomy in the prevention of breast tumors was studied in spontaneous breast-tumor-forming C3H mice. Prolactin levels were assayed to determine if this hormone was related to the incidence of mammary tumors. Two-hundred and fifty-six 1-month-old C3H mice were divided into four groups (control, 1; sham surgery, 2; mammectomy 50 percent, 3; and mammectomy 100 percent, 4). At the time of sacrifice (0 to 1 year postop-eratively) estrus cycles were determined, ventral skin (breast) and ovaries were removed for histology, and serum was collected for prolactin assays. Prolactin levels 24 hours postoperatively were significantly elevated (p < 0.01) in groups 2 to 4 when compared with group 1. Six months postoperatively, prolactin levels were significantly higher (p < 0.05) in mice with tumors compared with those without tumors in groups 3 and 4. There were no differences in tumor incidence between the four groups. At 12 months postoperatively, no differences in prolactin levels were noted, but group 2 animals had the highest incidence of mammary tumors (89 percent; p < 0.01) when compared to groups 3 and 4. Mammary tumor incidence was not decreased by 50 percent or 100 percent mammectomy in C3H mice. Prolactin levels rose in response to surgery and/or anesthesia and remained elevated only in tumor-bearing mice who underwent mammectomy, an occurrence similar to that reported in humans.

Original languageEnglish (US)
Pages (from-to)662-669
Number of pages8
JournalPlastic and Reconstructive Surgery
Volume83
Issue number4
StatePublished - Jan 1 1989
Externally publishedYes

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Inbred C3H Mouse
Prolactin
Mastectomy
Breast Neoplasms
Incidence
Neoplasms
Estrus
Prophylactic Mastectomy
Ovary
Histology
Breast
Anesthesia
Hormones
Control Groups
Skin
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Nelson, H., Miller, S. H., Buck, D., Demuth, R. J., Fletcher, W. S., & Buehler, P. (1989). Effectiveness of prophylactic mastectomy in the prevention of breast tumors in C3H mice. Plastic and Reconstructive Surgery, 83(4), 662-669.

Effectiveness of prophylactic mastectomy in the prevention of breast tumors in C3H mice. / Nelson, Heidi; Miller, Stephen H.; Buck, David; Demuth, Robert J.; Fletcher, William S.; Buehler, Peter.

In: Plastic and Reconstructive Surgery, Vol. 83, No. 4, 01.01.1989, p. 662-669.

Research output: Contribution to journalArticle

Nelson, H, Miller, SH, Buck, D, Demuth, RJ, Fletcher, WS & Buehler, P 1989, 'Effectiveness of prophylactic mastectomy in the prevention of breast tumors in C3H mice', Plastic and Reconstructive Surgery, vol. 83, no. 4, pp. 662-669.
Nelson, Heidi ; Miller, Stephen H. ; Buck, David ; Demuth, Robert J. ; Fletcher, William S. ; Buehler, Peter. / Effectiveness of prophylactic mastectomy in the prevention of breast tumors in C3H mice. In: Plastic and Reconstructive Surgery. 1989 ; Vol. 83, No. 4. pp. 662-669.
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