Effectiveness of inactivated influenza vaccine in children less than 5 years of age over multiple influenza seasons: A case-control study

Avni Y. Joshi, Vivek N. Iyer, Jennifer St. Sauver, Robert M. Jacobson, Thomas G. Boyce

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The effectiveness of influenza vaccine over multiple influenza seasons in children less than 5 years of age has not been well studied. This is especially important to assess because of the recent recommendation for routine influenza vaccination in childhood. We conducted a matched case-control study to assess the vaccine effectiveness of Trivalent Inactivated Influenza Vaccine (TIV) against laboratory-confirmed, medically attended influenza among children 6-59 months of age at the start of each influenza season from 1999-2000 through 2006-2007 in Olmsted County, MN, USA. The children vaccinated against influenza accordingly to the 2007 ACIP guidelines had a lower risk of laboratory-confirmed medically attended influenza illness (Odds Ratio: 0.14, 95% Confidence Interval: 0.03-0.71) than the unvaccinated children. TIV provided strong protection against laboratory-confirmed medically attended influenza in children 6-59 months old in the fully vaccinated group. This trend continued in the partially vaccinated group (Odds Ratio: 0.27, 95% Confidence Interval: 0.07-0.97) but the protection provided maybe suboptimal.

Original languageEnglish (US)
Pages (from-to)4457-4461
Number of pages5
JournalVaccine
Volume27
Issue number33
DOIs
StatePublished - Jul 16 2009

Fingerprint

Inactivated Vaccines
Influenza Vaccines
case-control studies
influenza
Human Influenza
Case-Control Studies
vaccines
Odds Ratio
Confidence Intervals
odds ratio
confidence interval
Vaccination
Vaccines
Guidelines
childhood
vaccination

Keywords

  • Children
  • Effectiveness
  • Influenza
  • Trivalent Inactivated Influenza vaccine (TIV)

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

Effectiveness of inactivated influenza vaccine in children less than 5 years of age over multiple influenza seasons : A case-control study. / Joshi, Avni Y.; Iyer, Vivek N.; St. Sauver, Jennifer; Jacobson, Robert M.; Boyce, Thomas G.

In: Vaccine, Vol. 27, No. 33, 16.07.2009, p. 4457-4461.

Research output: Contribution to journalArticle

Joshi, Avni Y. ; Iyer, Vivek N. ; St. Sauver, Jennifer ; Jacobson, Robert M. ; Boyce, Thomas G. / Effectiveness of inactivated influenza vaccine in children less than 5 years of age over multiple influenza seasons : A case-control study. In: Vaccine. 2009 ; Vol. 27, No. 33. pp. 4457-4461.
@article{93fd32539fe14b62bd94202777cbf20a,
title = "Effectiveness of inactivated influenza vaccine in children less than 5 years of age over multiple influenza seasons: A case-control study",
abstract = "The effectiveness of influenza vaccine over multiple influenza seasons in children less than 5 years of age has not been well studied. This is especially important to assess because of the recent recommendation for routine influenza vaccination in childhood. We conducted a matched case-control study to assess the vaccine effectiveness of Trivalent Inactivated Influenza Vaccine (TIV) against laboratory-confirmed, medically attended influenza among children 6-59 months of age at the start of each influenza season from 1999-2000 through 2006-2007 in Olmsted County, MN, USA. The children vaccinated against influenza accordingly to the 2007 ACIP guidelines had a lower risk of laboratory-confirmed medically attended influenza illness (Odds Ratio: 0.14, 95{\%} Confidence Interval: 0.03-0.71) than the unvaccinated children. TIV provided strong protection against laboratory-confirmed medically attended influenza in children 6-59 months old in the fully vaccinated group. This trend continued in the partially vaccinated group (Odds Ratio: 0.27, 95{\%} Confidence Interval: 0.07-0.97) but the protection provided maybe suboptimal.",
keywords = "Children, Effectiveness, Influenza, Trivalent Inactivated Influenza vaccine (TIV)",
author = "Joshi, {Avni Y.} and Iyer, {Vivek N.} and {St. Sauver}, Jennifer and Jacobson, {Robert M.} and Boyce, {Thomas G.}",
year = "2009",
month = "7",
day = "16",
doi = "10.1016/j.vaccine.2009.05.038",
language = "English (US)",
volume = "27",
pages = "4457--4461",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "33",

}

TY - JOUR

T1 - Effectiveness of inactivated influenza vaccine in children less than 5 years of age over multiple influenza seasons

T2 - A case-control study

AU - Joshi, Avni Y.

AU - Iyer, Vivek N.

AU - St. Sauver, Jennifer

AU - Jacobson, Robert M.

AU - Boyce, Thomas G.

PY - 2009/7/16

Y1 - 2009/7/16

N2 - The effectiveness of influenza vaccine over multiple influenza seasons in children less than 5 years of age has not been well studied. This is especially important to assess because of the recent recommendation for routine influenza vaccination in childhood. We conducted a matched case-control study to assess the vaccine effectiveness of Trivalent Inactivated Influenza Vaccine (TIV) against laboratory-confirmed, medically attended influenza among children 6-59 months of age at the start of each influenza season from 1999-2000 through 2006-2007 in Olmsted County, MN, USA. The children vaccinated against influenza accordingly to the 2007 ACIP guidelines had a lower risk of laboratory-confirmed medically attended influenza illness (Odds Ratio: 0.14, 95% Confidence Interval: 0.03-0.71) than the unvaccinated children. TIV provided strong protection against laboratory-confirmed medically attended influenza in children 6-59 months old in the fully vaccinated group. This trend continued in the partially vaccinated group (Odds Ratio: 0.27, 95% Confidence Interval: 0.07-0.97) but the protection provided maybe suboptimal.

AB - The effectiveness of influenza vaccine over multiple influenza seasons in children less than 5 years of age has not been well studied. This is especially important to assess because of the recent recommendation for routine influenza vaccination in childhood. We conducted a matched case-control study to assess the vaccine effectiveness of Trivalent Inactivated Influenza Vaccine (TIV) against laboratory-confirmed, medically attended influenza among children 6-59 months of age at the start of each influenza season from 1999-2000 through 2006-2007 in Olmsted County, MN, USA. The children vaccinated against influenza accordingly to the 2007 ACIP guidelines had a lower risk of laboratory-confirmed medically attended influenza illness (Odds Ratio: 0.14, 95% Confidence Interval: 0.03-0.71) than the unvaccinated children. TIV provided strong protection against laboratory-confirmed medically attended influenza in children 6-59 months old in the fully vaccinated group. This trend continued in the partially vaccinated group (Odds Ratio: 0.27, 95% Confidence Interval: 0.07-0.97) but the protection provided maybe suboptimal.

KW - Children

KW - Effectiveness

KW - Influenza

KW - Trivalent Inactivated Influenza vaccine (TIV)

UR - http://www.scopus.com/inward/record.url?scp=67649378412&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649378412&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2009.05.038

DO - 10.1016/j.vaccine.2009.05.038

M3 - Article

C2 - 19490957

AN - SCOPUS:67649378412

VL - 27

SP - 4457

EP - 4461

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 33

ER -