Effectiveness of inactivated influenza vaccine in children less than 5 years of age over multiple influenza seasons: A case-control study

Avni Y. Joshi, Vivek N. Iyer, Jennifer L. St. Sauver, Robert M. Jacobson, Thomas G. Boyce

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The effectiveness of influenza vaccine over multiple influenza seasons in children less than 5 years of age has not been well studied. This is especially important to assess because of the recent recommendation for routine influenza vaccination in childhood. We conducted a matched case-control study to assess the vaccine effectiveness of Trivalent Inactivated Influenza Vaccine (TIV) against laboratory-confirmed, medically attended influenza among children 6-59 months of age at the start of each influenza season from 1999-2000 through 2006-2007 in Olmsted County, MN, USA. The children vaccinated against influenza accordingly to the 2007 ACIP guidelines had a lower risk of laboratory-confirmed medically attended influenza illness (Odds Ratio: 0.14, 95% Confidence Interval: 0.03-0.71) than the unvaccinated children. TIV provided strong protection against laboratory-confirmed medically attended influenza in children 6-59 months old in the fully vaccinated group. This trend continued in the partially vaccinated group (Odds Ratio: 0.27, 95% Confidence Interval: 0.07-0.97) but the protection provided maybe suboptimal.

Original languageEnglish (US)
Pages (from-to)4457-4461
Number of pages5
JournalVaccine
Volume27
Issue number33
DOIs
StatePublished - Jul 16 2009

Keywords

  • Children
  • Effectiveness
  • Influenza
  • Trivalent Inactivated Influenza vaccine (TIV)

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Effectiveness of inactivated influenza vaccine in children less than 5 years of age over multiple influenza seasons: A case-control study'. Together they form a unique fingerprint.

  • Cite this