Effectiveness of Carotid Endarterectomy for Asymptomatic Carotid Stenosis: Design of a Clinical Trial

MAYO ASYMPTOMATIC CAROTID ENDARTERECTOMY STUDY GROUP

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A clinical trial, as described in this report, has been designed to compare the effects of carotid endarterectomy and medical treatment with aspirin for prevention of transient ischemic attack, reversible ischemic neurologic deficit, and ischemic stroke in patients with asymptomatic pressure-significant carotid stenosis. A prospective randomized controlled trial design is being used, and selection of patients with asymptomatic pressure-significant carotid stenosis is based on the results of ocular pneumoplethysmography and either duplex ultrasound scanning or digital subtraction angiography. Patients are randomized to either surgical (carotid endarterectomy) or medical (aspirin, 80 mg/day) treatment, and follow-up assessment is accomplished by return visits and patient questionnaires. A total of 945 patient-years of follow-up will be accumulated for each of the medical and surgical groups.

Original languageEnglish (US)
Pages (from-to)897-904
Number of pages8
JournalMayo Clinic Proceedings
Volume64
Issue number8
DOIs
StatePublished - 1989

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Carotid Endarterectomy
Carotid Stenosis
Clinical Trials
Aspirin
Pressure
Digital Subtraction Angiography
Transient Ischemic Attack
Neurologic Manifestations
Patient Selection
Randomized Controlled Trials
Stroke
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effectiveness of Carotid Endarterectomy for Asymptomatic Carotid Stenosis : Design of a Clinical Trial. / MAYO ASYMPTOMATIC CAROTID ENDARTERECTOMY STUDY GROUP.

In: Mayo Clinic Proceedings, Vol. 64, No. 8, 1989, p. 897-904.

Research output: Contribution to journalArticle

MAYO ASYMPTOMATIC CAROTID ENDARTERECTOMY STUDY GROUP. / Effectiveness of Carotid Endarterectomy for Asymptomatic Carotid Stenosis : Design of a Clinical Trial. In: Mayo Clinic Proceedings. 1989 ; Vol. 64, No. 8. pp. 897-904.
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