Effect on CD4 T-cell count of replacing protease inhibitors in patients with successful HIV suppression: A meta-analysis

Carolyn Owen, Farouk Kazim, Andrew D. Badley

Research output: Contribution to journalArticle

3 Scopus citations


Protease inhibitor (PI) therapy may be associated with adverse events. Switching the PI component to a non-PI may reduce some side-effects, but the immune effects are unclear. In a meta-analysis using strict inclusion criteria, a randomized switch from PI was associated with impaired CD4 T-cell gains compared with maintaining PI (PI arm +32 cells, effect size 0.130, P = 0.05). Therefore, PI-based therapy results in superior CD4 T-cell gains compared with switching to a non-PI regimen.

Original languageEnglish (US)
Pages (from-to)693-695
Number of pages3
Issue number4
StatePublished - Mar 5 2004


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this