Effect of Ventricular Arrhythmia Ablation in Patients With Heart Mate II Left Ventricular Assist Devices

An Evaluation of Ablation Therapy

David Snipelisky, Yogesh N V Reddy, Kevin Manocha, Aalok Patel, Shannon M Dunlay, Paul Andrew Friedman, Thomas M. Munger, Samuel J Asirvatham, Douglas L Packer, Yong-Mei Cha, Suraj Kapa, Peter A. Brady, Peter Noseworthy, Joseph Maleszewski, Siva Mulpuru

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

VT Ablation in LVAD Recipients: Background: Patients with advanced heart failure (HF) are predisposed to ventricular arrhythmias (VAs), particularly following implantation of a left ventricular assist device (LVAD). There is minimal evidence for appropriate management strategies. Objectives: This study aimed to compare the burden of VA and response to ablation performed either before or following LVAD implantation. Methods: We created a retrospective cohort of patients who underwent both VA ablation and Heart Mate II (Thoratec, Pleasanton, CA, USA) LVAD implantation at Mayo Clinic (Rochester, MN, USA). Patients were stratified based on whether they underwent VA ablation before (pre-LVAD) or after LVAD (post-LVAD) implantation. Descriptive analyses assessed 6-month arrhythmia burden in relation to LVAD implantation and VA ablation. Results: A total of 9 patients underwent both LVAD implantation and VA ablation. There were 3 and 6 patients, respectively, in the pre-LVAD and post-LVAD cohorts. Among patients in the pre-LVAD cohort, the median number of VAs tended to increase after ablation (9 vs. 72) and decreased after LVAD implantation (72 vs. 63). Similarly among patients in the post-LVAD cohort, the median burden of VAs increased after LVAD implantation (1 vs. 22) and the median burden decreased after ablation (22 vs. 13). Two of 6 patients had substrate related to the LVAD inflow cannula site, while other substrate was not related directly to the cannula. Conclusions: In patients with progressive HF and LVAD implantation, ablation is associated with reduced VA rates. In LVAD patients, most VAs arise from substrate unrelated to the inflow cannula site. Journal compilation

Original languageEnglish (US)
JournalJournal of Cardiovascular Electrophysiology
DOIs
StateAccepted/In press - 2016

Fingerprint

Heart-Assist Devices
Cardiac Arrhythmias
Therapeutics
Heart Failure

Keywords

  • Catheter ablation
  • Heart failure
  • Heart Mate II
  • Left ventricular assist device
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

@article{b5065a492c354f7ba3b5d2851e088b7b,
title = "Effect of Ventricular Arrhythmia Ablation in Patients With Heart Mate II Left Ventricular Assist Devices: An Evaluation of Ablation Therapy",
abstract = "VT Ablation in LVAD Recipients: Background: Patients with advanced heart failure (HF) are predisposed to ventricular arrhythmias (VAs), particularly following implantation of a left ventricular assist device (LVAD). There is minimal evidence for appropriate management strategies. Objectives: This study aimed to compare the burden of VA and response to ablation performed either before or following LVAD implantation. Methods: We created a retrospective cohort of patients who underwent both VA ablation and Heart Mate II (Thoratec, Pleasanton, CA, USA) LVAD implantation at Mayo Clinic (Rochester, MN, USA). Patients were stratified based on whether they underwent VA ablation before (pre-LVAD) or after LVAD (post-LVAD) implantation. Descriptive analyses assessed 6-month arrhythmia burden in relation to LVAD implantation and VA ablation. Results: A total of 9 patients underwent both LVAD implantation and VA ablation. There were 3 and 6 patients, respectively, in the pre-LVAD and post-LVAD cohorts. Among patients in the pre-LVAD cohort, the median number of VAs tended to increase after ablation (9 vs. 72) and decreased after LVAD implantation (72 vs. 63). Similarly among patients in the post-LVAD cohort, the median burden of VAs increased after LVAD implantation (1 vs. 22) and the median burden decreased after ablation (22 vs. 13). Two of 6 patients had substrate related to the LVAD inflow cannula site, while other substrate was not related directly to the cannula. Conclusions: In patients with progressive HF and LVAD implantation, ablation is associated with reduced VA rates. In LVAD patients, most VAs arise from substrate unrelated to the inflow cannula site. Journal compilation",
keywords = "Catheter ablation, Heart failure, Heart Mate II, Left ventricular assist device, Ventricular tachycardia",
author = "David Snipelisky and Reddy, {Yogesh N V} and Kevin Manocha and Aalok Patel and Dunlay, {Shannon M} and Friedman, {Paul Andrew} and Munger, {Thomas M.} and Asirvatham, {Samuel J} and Packer, {Douglas L} and Yong-Mei Cha and Suraj Kapa and Brady, {Peter A.} and Peter Noseworthy and Joseph Maleszewski and Siva Mulpuru",
year = "2016",
doi = "10.1111/jce.13114",
language = "English (US)",
journal = "Journal of Cardiovascular Electrophysiology",
issn = "1045-3873",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Effect of Ventricular Arrhythmia Ablation in Patients With Heart Mate II Left Ventricular Assist Devices

T2 - An Evaluation of Ablation Therapy

AU - Snipelisky, David

AU - Reddy, Yogesh N V

AU - Manocha, Kevin

AU - Patel, Aalok

AU - Dunlay, Shannon M

AU - Friedman, Paul Andrew

AU - Munger, Thomas M.

AU - Asirvatham, Samuel J

AU - Packer, Douglas L

AU - Cha, Yong-Mei

AU - Kapa, Suraj

AU - Brady, Peter A.

AU - Noseworthy, Peter

AU - Maleszewski, Joseph

AU - Mulpuru, Siva

PY - 2016

Y1 - 2016

N2 - VT Ablation in LVAD Recipients: Background: Patients with advanced heart failure (HF) are predisposed to ventricular arrhythmias (VAs), particularly following implantation of a left ventricular assist device (LVAD). There is minimal evidence for appropriate management strategies. Objectives: This study aimed to compare the burden of VA and response to ablation performed either before or following LVAD implantation. Methods: We created a retrospective cohort of patients who underwent both VA ablation and Heart Mate II (Thoratec, Pleasanton, CA, USA) LVAD implantation at Mayo Clinic (Rochester, MN, USA). Patients were stratified based on whether they underwent VA ablation before (pre-LVAD) or after LVAD (post-LVAD) implantation. Descriptive analyses assessed 6-month arrhythmia burden in relation to LVAD implantation and VA ablation. Results: A total of 9 patients underwent both LVAD implantation and VA ablation. There were 3 and 6 patients, respectively, in the pre-LVAD and post-LVAD cohorts. Among patients in the pre-LVAD cohort, the median number of VAs tended to increase after ablation (9 vs. 72) and decreased after LVAD implantation (72 vs. 63). Similarly among patients in the post-LVAD cohort, the median burden of VAs increased after LVAD implantation (1 vs. 22) and the median burden decreased after ablation (22 vs. 13). Two of 6 patients had substrate related to the LVAD inflow cannula site, while other substrate was not related directly to the cannula. Conclusions: In patients with progressive HF and LVAD implantation, ablation is associated with reduced VA rates. In LVAD patients, most VAs arise from substrate unrelated to the inflow cannula site. Journal compilation

AB - VT Ablation in LVAD Recipients: Background: Patients with advanced heart failure (HF) are predisposed to ventricular arrhythmias (VAs), particularly following implantation of a left ventricular assist device (LVAD). There is minimal evidence for appropriate management strategies. Objectives: This study aimed to compare the burden of VA and response to ablation performed either before or following LVAD implantation. Methods: We created a retrospective cohort of patients who underwent both VA ablation and Heart Mate II (Thoratec, Pleasanton, CA, USA) LVAD implantation at Mayo Clinic (Rochester, MN, USA). Patients were stratified based on whether they underwent VA ablation before (pre-LVAD) or after LVAD (post-LVAD) implantation. Descriptive analyses assessed 6-month arrhythmia burden in relation to LVAD implantation and VA ablation. Results: A total of 9 patients underwent both LVAD implantation and VA ablation. There were 3 and 6 patients, respectively, in the pre-LVAD and post-LVAD cohorts. Among patients in the pre-LVAD cohort, the median number of VAs tended to increase after ablation (9 vs. 72) and decreased after LVAD implantation (72 vs. 63). Similarly among patients in the post-LVAD cohort, the median burden of VAs increased after LVAD implantation (1 vs. 22) and the median burden decreased after ablation (22 vs. 13). Two of 6 patients had substrate related to the LVAD inflow cannula site, while other substrate was not related directly to the cannula. Conclusions: In patients with progressive HF and LVAD implantation, ablation is associated with reduced VA rates. In LVAD patients, most VAs arise from substrate unrelated to the inflow cannula site. Journal compilation

KW - Catheter ablation

KW - Heart failure

KW - Heart Mate II

KW - Left ventricular assist device

KW - Ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=85006043545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006043545&partnerID=8YFLogxK

U2 - 10.1111/jce.13114

DO - 10.1111/jce.13114

M3 - Article

JO - Journal of Cardiovascular Electrophysiology

JF - Journal of Cardiovascular Electrophysiology

SN - 1045-3873

ER -