Abstract
Background: Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD. Purpose: To determine the relationship between multiple vascular risk exposures, as counted on an index in cases with VaD, compared with healthy age-/gender-matched controls. Methods: This was a matched case-control study of subjects living in Olmsted County, MN with documented VaD. Controls were selected by gender and age within 3 years from those who did not have dementia. The exposures included a total index (eleven exposure factors) added together, along with indexes for cerebrovascular disease (two exposures), cardiovascular disease (four exposures), vascular disease (three exposures), and lifestyle (two exposures). Analysis used matched conditional univariable logistic regression for each index. Results: A total of 1736 potential subjects were identified, and 205 subjects were diagnosed with VaD. There was a significant association of the total score index with an odds ratio of 1.45 (95% confidence interval 1.21-1.74). The cerebrovascular index was also associated with VaD with an odds ratio of 12.18 (95% confidence interval 6.29-23.61). The cardiovascular and vascular indexes were also associated with VaD status. The lifestyle index was not associated with VaD. Conclusion: The cumulative role of multiple vascular risk factors or diseases increased the risk of VaD, as noted by the total vascular index. The lifestyle index did not reveal any significant differences. Further work is required for evaluation of these indexes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-33 |
| Number of pages | 7 |
| Journal | Clinical Interventions in Aging |
| Volume | 7 |
| DOIs | |
| State | Published - 2012 |
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Keywords
- Elderly
- Polyvascular disease
- Vascular dementia
ASJC Scopus subject areas
- Geriatrics and Gerontology
Cite this
Effect of vascular burden as measured by vascular indexes upon vascular dementia : A matched case-control study. / Takahashi, Paul Y; Caldwell, Casey R.; Targonski, Paul V.
In: Clinical Interventions in Aging, Vol. 7, 2012, p. 27-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of vascular burden as measured by vascular indexes upon vascular dementia
T2 - A matched case-control study
AU - Takahashi, Paul Y
AU - Caldwell, Casey R.
AU - Targonski, Paul V.
PY - 2012
Y1 - 2012
N2 - Background: Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD. Purpose: To determine the relationship between multiple vascular risk exposures, as counted on an index in cases with VaD, compared with healthy age-/gender-matched controls. Methods: This was a matched case-control study of subjects living in Olmsted County, MN with documented VaD. Controls were selected by gender and age within 3 years from those who did not have dementia. The exposures included a total index (eleven exposure factors) added together, along with indexes for cerebrovascular disease (two exposures), cardiovascular disease (four exposures), vascular disease (three exposures), and lifestyle (two exposures). Analysis used matched conditional univariable logistic regression for each index. Results: A total of 1736 potential subjects were identified, and 205 subjects were diagnosed with VaD. There was a significant association of the total score index with an odds ratio of 1.45 (95% confidence interval 1.21-1.74). The cerebrovascular index was also associated with VaD with an odds ratio of 12.18 (95% confidence interval 6.29-23.61). The cardiovascular and vascular indexes were also associated with VaD status. The lifestyle index was not associated with VaD. Conclusion: The cumulative role of multiple vascular risk factors or diseases increased the risk of VaD, as noted by the total vascular index. The lifestyle index did not reveal any significant differences. Further work is required for evaluation of these indexes.
AB - Background: Vascular dementia (VaD) is a challenging illness that affects the lives of older adults and caregivers. It is unclear how multiple vascular risk factor exposures (polyvascular disease) affect VaD. Purpose: To determine the relationship between multiple vascular risk exposures, as counted on an index in cases with VaD, compared with healthy age-/gender-matched controls. Methods: This was a matched case-control study of subjects living in Olmsted County, MN with documented VaD. Controls were selected by gender and age within 3 years from those who did not have dementia. The exposures included a total index (eleven exposure factors) added together, along with indexes for cerebrovascular disease (two exposures), cardiovascular disease (four exposures), vascular disease (three exposures), and lifestyle (two exposures). Analysis used matched conditional univariable logistic regression for each index. Results: A total of 1736 potential subjects were identified, and 205 subjects were diagnosed with VaD. There was a significant association of the total score index with an odds ratio of 1.45 (95% confidence interval 1.21-1.74). The cerebrovascular index was also associated with VaD with an odds ratio of 12.18 (95% confidence interval 6.29-23.61). The cardiovascular and vascular indexes were also associated with VaD status. The lifestyle index was not associated with VaD. Conclusion: The cumulative role of multiple vascular risk factors or diseases increased the risk of VaD, as noted by the total vascular index. The lifestyle index did not reveal any significant differences. Further work is required for evaluation of these indexes.
KW - Elderly
KW - Polyvascular disease
KW - Vascular dementia
UR - http://www.scopus.com/inward/record.url?scp=84857100217&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857100217&partnerID=8YFLogxK
U2 - 10.2147/CIA.S28143
DO - 10.2147/CIA.S28143
M3 - Article
C2 - 22291470
AN - SCOPUS:84857100217
VL - 7
SP - 27
EP - 33
JO - Clinical Interventions in Aging
JF - Clinical Interventions in Aging
SN - 1176-9092
ER -