Effect of tubal sterilization technique on risk of serous epithelial ovarian and primary peritoneal carcinoma

Collette R. Lessard-Anderson, Kathryn S. Handlogten, Rochelle J. Molitor, Sean Christopher Dowdy, William Arthur Cliby, Amy L. Weaver, Jennifer St. Sauver, Jamie N Bakkum-Gamez

Research output: Contribution to journalArticle

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Abstract

Objective. To determine the effect of excisional tubal sterilization on subsequent development of serous epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC). Methods. We performed a population-based, nested case-control study using the Rochester Epidemiology Project. We identified all patients with a diagnosis of serous EOC or PPC from 1966 through 2009. Each case was age-matched to 2 controls without either diagnosis. Odds ratios (ORs) and corresponding 95% CIs were estimated from conditional logistic regression models. Models were adjusted for prior hysterectomy, prior salpingo-oophorectomy, oral contraceptive use, endometriosis, infertility, gravidity, and parity. Results. In total, we identified 194 cases of serous EOC and PPC during the study period and matched them with 388 controls (mean [SD] age, 61.4 [15.2] years). Fourteen cases (7.2%) and 46 controls (11.9%) had undergone tubal sterilization. Adjusted risk of serous EOC or PPC was slightly lower after any tubal sterilization (OR, 0.59 [95% CI, 0.29-1.17]; P = .13). The rate of excisional tubal sterilization was lower in cases than controls (2.6% vs 6.4%). Adjusted risk of serous EOC and PPC was decreased by 64% after excisional tubal sterilization (OR, 0.36 [95% CI, 0.13-1.02]; P = .054) compared with those without sterilization or with nonexcisional tubal sterilization. Conclusions. We present a population-based investigation of the effects of excisional tubal sterilization on the risk of serous EOC and PPC. Excisional methods may confer greater risk reduction than other sterilization methods.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalGynecologic Oncology
Volume135
Issue number3
DOIs
StatePublished - Dec 1 2014

Fingerprint

Tubal Sterilization
Carcinoma
Neoplasms
Odds Ratio
Logistic Models
Gravidity
Ovariectomy
Endometriosis
Risk Reduction Behavior
Oral Contraceptives
Parity
Hysterectomy
Infertility
Population
Ovarian epithelial cancer
Case-Control Studies
Epidemiology

Keywords

  • Fimbriectomy
  • Salpingectomy
  • Serous ovarian cancer
  • Serous primary peritoneal cancer
  • Tubal sterilization

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Effect of tubal sterilization technique on risk of serous epithelial ovarian and primary peritoneal carcinoma. / Lessard-Anderson, Collette R.; Handlogten, Kathryn S.; Molitor, Rochelle J.; Dowdy, Sean Christopher; Cliby, William Arthur; Weaver, Amy L.; St. Sauver, Jennifer; Bakkum-Gamez, Jamie N.

In: Gynecologic Oncology, Vol. 135, No. 3, 01.12.2014, p. 423-427.

Research output: Contribution to journalArticle

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abstract = "Objective. To determine the effect of excisional tubal sterilization on subsequent development of serous epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC). Methods. We performed a population-based, nested case-control study using the Rochester Epidemiology Project. We identified all patients with a diagnosis of serous EOC or PPC from 1966 through 2009. Each case was age-matched to 2 controls without either diagnosis. Odds ratios (ORs) and corresponding 95{\%} CIs were estimated from conditional logistic regression models. Models were adjusted for prior hysterectomy, prior salpingo-oophorectomy, oral contraceptive use, endometriosis, infertility, gravidity, and parity. Results. In total, we identified 194 cases of serous EOC and PPC during the study period and matched them with 388 controls (mean [SD] age, 61.4 [15.2] years). Fourteen cases (7.2{\%}) and 46 controls (11.9{\%}) had undergone tubal sterilization. Adjusted risk of serous EOC or PPC was slightly lower after any tubal sterilization (OR, 0.59 [95{\%} CI, 0.29-1.17]; P = .13). The rate of excisional tubal sterilization was lower in cases than controls (2.6{\%} vs 6.4{\%}). Adjusted risk of serous EOC and PPC was decreased by 64{\%} after excisional tubal sterilization (OR, 0.36 [95{\%} CI, 0.13-1.02]; P = .054) compared with those without sterilization or with nonexcisional tubal sterilization. Conclusions. We present a population-based investigation of the effects of excisional tubal sterilization on the risk of serous EOC and PPC. Excisional methods may confer greater risk reduction than other sterilization methods.",
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AU - Handlogten, Kathryn S.

AU - Molitor, Rochelle J.

AU - Dowdy, Sean Christopher

AU - Cliby, William Arthur

AU - Weaver, Amy L.

AU - St. Sauver, Jennifer

AU - Bakkum-Gamez, Jamie N

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AB - Objective. To determine the effect of excisional tubal sterilization on subsequent development of serous epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC). Methods. We performed a population-based, nested case-control study using the Rochester Epidemiology Project. We identified all patients with a diagnosis of serous EOC or PPC from 1966 through 2009. Each case was age-matched to 2 controls without either diagnosis. Odds ratios (ORs) and corresponding 95% CIs were estimated from conditional logistic regression models. Models were adjusted for prior hysterectomy, prior salpingo-oophorectomy, oral contraceptive use, endometriosis, infertility, gravidity, and parity. Results. In total, we identified 194 cases of serous EOC and PPC during the study period and matched them with 388 controls (mean [SD] age, 61.4 [15.2] years). Fourteen cases (7.2%) and 46 controls (11.9%) had undergone tubal sterilization. Adjusted risk of serous EOC or PPC was slightly lower after any tubal sterilization (OR, 0.59 [95% CI, 0.29-1.17]; P = .13). The rate of excisional tubal sterilization was lower in cases than controls (2.6% vs 6.4%). Adjusted risk of serous EOC and PPC was decreased by 64% after excisional tubal sterilization (OR, 0.36 [95% CI, 0.13-1.02]; P = .054) compared with those without sterilization or with nonexcisional tubal sterilization. Conclusions. We present a population-based investigation of the effects of excisional tubal sterilization on the risk of serous EOC and PPC. Excisional methods may confer greater risk reduction than other sterilization methods.

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