Effect of topical calcium channel blockers on intraocular pressure in steroid-induced glaucoma

Sunil Ganekal, Syril Dorairaj, Vishal Jhanji, Krishnaprasad Kudlu

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Purpose: To evaluate the effect of 0.125% verapamil and 0.5% diltiazem eye drops on intraocular pressure (IOP) in steroid-induced glaucoma in rabbit eyes. Methods: A total of 18 rabbits with steroid-induced glaucoma were divided into three groups (A, B and C; n = 6 each). Right eyes in groups A, B and C received 0.5% diltiazem, 0.125% verapamil and 0.5% timolol eye drops twice daily for 12 days, respectively; whereas, left eyes received distilled water. IOP was measured with Tono-pen XL at baseline, day 4, day 8, and day 12 of treatment. Results: Both 0.5% diltiazem and 0.125% verapamil eye drops significantly reduced IOP compared to control eyes (p < 0.05). Reduction of IOP by 0.5% diltiazem, 0.125% verapamil eye drops were comparable to 0.5% timolol. No surface toxicity or systemic side effects were noted during the study period. Conclusion: Calcium channel blockers, verapamil, and diltiazem significantly reduced IOP in rabbit eyes. This group of drugs may have a potential role in treatment of glaucoma.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalJournal of Current Glaucoma Practice
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Calcium channel blockers
  • Intraocular pressure
  • Steroid-induced glaucoma

ASJC Scopus subject areas

  • Ophthalmology

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