Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion

N. D. Croughwell, M. F. Newman, E. Lowry, R. D. Davis, K. P. Landolfo, W. D. White, J. L. Kirchner, M. G. Mythen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The purpose of our study was to prospectively study the splanchnic response to hypothermic and tepid cardiopulmonary bypass (CPB) using alpha-stat management of arterial blood gas tensions. Twenty-four patients for elective CABG surgery were allocated randomly to tepid (35-36°C) or hypothermic (30°C) bypass groups. Measurements were made at four times: (1) baseline, (2) stable during CPB (inflow temperature=nasopharyngeal temperature) 30°C for hypothermic patients, bypass +20 min for tepid patients, (3) 10 min before the end of bypass, (4) after bypass, skin closure. Both groups demonstrated a significant reduction in gastric intramucosal pH (pH(im)) from time 1 to time 4 and there was no difference in the incidence of a low pH(im) between the tepid and cold groups (4/12 vs 3/12; ns) at time 4. pH(im) was significantly lower in the tepid group at time 3 (P = 0.03) but this discrepancy may have been because of an artefactually high pH(im) in the cold group. There was a significantly higher incidence of postoperative non-cardiac complications in patients who had a low pH(im) at time 4 (P = 0.0008) Therefore, we conclude that although the temperature during CPB had a transient effect on pH(im) it is unlikely to be a major determinant in the pathogenesis of gut mucosal hypoperfusion after bypass.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalBritish Journal of Anaesthesia
Volume78
Issue number1
StatePublished - Jan 1997
Externally publishedYes

Fingerprint

Cardiopulmonary Bypass
Stomach
Perfusion
Temperature
Viscera
Incidence
Gases
Skin

Keywords

  • Gastrointestinal tract, mucosal perfusion
  • Gastrointestinal tract, pH
  • Heart, cardiopulmonary bypass
  • Surgery, cardiovascular
  • Temperature, effect

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Croughwell, N. D., Newman, M. F., Lowry, E., Davis, R. D., Landolfo, K. P., White, W. D., ... Mythen, M. G. (1997). Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion. British Journal of Anaesthesia, 78(1), 34-38.

Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion. / Croughwell, N. D.; Newman, M. F.; Lowry, E.; Davis, R. D.; Landolfo, K. P.; White, W. D.; Kirchner, J. L.; Mythen, M. G.

In: British Journal of Anaesthesia, Vol. 78, No. 1, 01.1997, p. 34-38.

Research output: Contribution to journalArticle

Croughwell, ND, Newman, MF, Lowry, E, Davis, RD, Landolfo, KP, White, WD, Kirchner, JL & Mythen, MG 1997, 'Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion', British Journal of Anaesthesia, vol. 78, no. 1, pp. 34-38.
Croughwell ND, Newman MF, Lowry E, Davis RD, Landolfo KP, White WD et al. Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion. British Journal of Anaesthesia. 1997 Jan;78(1):34-38.
Croughwell, N. D. ; Newman, M. F. ; Lowry, E. ; Davis, R. D. ; Landolfo, K. P. ; White, W. D. ; Kirchner, J. L. ; Mythen, M. G. / Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion. In: British Journal of Anaesthesia. 1997 ; Vol. 78, No. 1. pp. 34-38.
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