Effect of supine posture on airway blood flow and pulmonary function in stable heart failure

Maile L. Ceridon, Norman R. Morris, Thomas P Olson, Sophie Lalande, Bruce David Johnson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The aim of this study was to determine the relationship between body position, pulmonary function (PF) and bronchial blood flow (Q aw) in a group of heart failure (HF) and control subjects. Methods: Thirty-six subjects were studied: 24 stable, ambulatory HF patients (HF: LVEF = 27. ±. 6%, age = 65. ±. 9 yr) and 12 age- and sex-matched controls (CTRL: LVEF = 60. ±. 7%, age = 62. ±. 8 yr). Measures of Q̇aw (soluble gas method) and PF were collected upright and following 30 min in the supine position. Results: Q̇aw was similar between groups and remained unchanged with body position. Declines in forced vital capacity (FVC) and forced expiratory volume in 1s (FEV 1) with the supine position were observed in both groups; declines in forced expiratory flow 25-75% (FEF 25-75) and FEF 75% (FEF 75) with the supine position were observed in the HF group only. Changes in Q̇aw were related to changes in PF only in the HF patient groups (ΔFVC, % predicted, r=-0.45, p<0.04, ΔFEV 1 r=-0.61, p<0.01, ΔFEV 1% predicted, r=-0.45, p<0.04). Conclusion: These data demonstrate that relationships between postural changes in Q̇aw and PF exist only in the HF population and that the bronchial circulation may contribute to postural PF decline in HF.

Original languageEnglish (US)
Pages (from-to)269-274
Number of pages6
JournalRespiratory Physiology and Neurobiology
Volume178
Issue number2
DOIs
StatePublished - Sep 15 2011

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Posture
Heart Failure
Lung
Supine Position
Forced Expiratory Volume
Vital Capacity
Gases
Population

Keywords

  • Bronchial blood flow
  • Left ventricular systolic dysfunction
  • Upright and supine position

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Effect of supine posture on airway blood flow and pulmonary function in stable heart failure. / Ceridon, Maile L.; Morris, Norman R.; Olson, Thomas P; Lalande, Sophie; Johnson, Bruce David.

In: Respiratory Physiology and Neurobiology, Vol. 178, No. 2, 15.09.2011, p. 269-274.

Research output: Contribution to journalArticle

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abstract = "Background: The aim of this study was to determine the relationship between body position, pulmonary function (PF) and bronchial blood flow (Q aw) in a group of heart failure (HF) and control subjects. Methods: Thirty-six subjects were studied: 24 stable, ambulatory HF patients (HF: LVEF = 27. ±. 6{\%}, age = 65. ±. 9 yr) and 12 age- and sex-matched controls (CTRL: LVEF = 60. ±. 7{\%}, age = 62. ±. 8 yr). Measures of Q̇aw (soluble gas method) and PF were collected upright and following 30 min in the supine position. Results: Q̇aw was similar between groups and remained unchanged with body position. Declines in forced vital capacity (FVC) and forced expiratory volume in 1s (FEV 1) with the supine position were observed in both groups; declines in forced expiratory flow 25-75{\%} (FEF 25-75) and FEF 75{\%} (FEF 75) with the supine position were observed in the HF group only. Changes in Q̇aw were related to changes in PF only in the HF patient groups (ΔFVC, {\%} predicted, r=-0.45, p<0.04, ΔFEV 1 r=-0.61, p<0.01, ΔFEV 1{\%} predicted, r=-0.45, p<0.04). Conclusion: These data demonstrate that relationships between postural changes in Q̇aw and PF exist only in the HF population and that the bronchial circulation may contribute to postural PF decline in HF.",
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N2 - Background: The aim of this study was to determine the relationship between body position, pulmonary function (PF) and bronchial blood flow (Q aw) in a group of heart failure (HF) and control subjects. Methods: Thirty-six subjects were studied: 24 stable, ambulatory HF patients (HF: LVEF = 27. ±. 6%, age = 65. ±. 9 yr) and 12 age- and sex-matched controls (CTRL: LVEF = 60. ±. 7%, age = 62. ±. 8 yr). Measures of Q̇aw (soluble gas method) and PF were collected upright and following 30 min in the supine position. Results: Q̇aw was similar between groups and remained unchanged with body position. Declines in forced vital capacity (FVC) and forced expiratory volume in 1s (FEV 1) with the supine position were observed in both groups; declines in forced expiratory flow 25-75% (FEF 25-75) and FEF 75% (FEF 75) with the supine position were observed in the HF group only. Changes in Q̇aw were related to changes in PF only in the HF patient groups (ΔFVC, % predicted, r=-0.45, p<0.04, ΔFEV 1 r=-0.61, p<0.01, ΔFEV 1% predicted, r=-0.45, p<0.04). Conclusion: These data demonstrate that relationships between postural changes in Q̇aw and PF exist only in the HF population and that the bronchial circulation may contribute to postural PF decline in HF.

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