Effect of sumatriptan, a new selective 5HT1‐like agonist, on liquid gastric emptying in man

L. A. HOUGHTON, P. FOWLER, O. N. KEENE, N. W. READ

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Paired studies were carried out on 12 healthy male subjects to compare the effect of intravenous doses of the 5‐HT1‐like agonist sumatriptan (GR43175; 3 mg), 10 mg metoclopramide and saline control on the rate of gastric emptying of a radiolabelled liquid test‐meal. Intravenous administration of metoclopramide accelerated gastric emptying by decreasing the lag period, while intravenous administration of sumatriptan delayed gastric emptying by increasing the lag period. The observation that sumatriptan causes a delay in gastric emptying in normal healthy volunteers, but relieves nausea and vomiting during migraine attacks, suggests that sumatriptan may be acting via a central mechanism to relieve symptoms of nausea and vomiting associated with migraine.

Original languageEnglish (US)
Pages (from-to)685-691
Number of pages7
JournalAlimentary pharmacology & therapeutics
Volume6
Issue number6
DOIs
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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