Effect of statins, smoking and obesity on progression of monoclonal gammopathy of undetermined significance: A case-control study

Michael A. Thompson, Robert A. Kyle, L. Joseph Melton, Matthew F. Plevak, S. Vincent Rajkumar

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Interleukin-6 (IL-6) and C-reactive protein (CRP, a surrogate marker for IL-6) are important in monoclonal gammopathy of undetermined significance (MGUS) and myeloma. Smoking and obesity may elevate CRP levels, while statins decrease CRP levels. A case-control study in 200 MGUS patients found that statin use, smoking history and obesity do not affect MGUS progression.

Original languageEnglish (US)
Pages (from-to)626-628
Number of pages3
JournalHaematologica
Volume89
Issue number5
StatePublished - May 2004

Keywords

  • Hydroxymethylglutaryl-CoA reductose inhibitors
  • MGUS
  • Myeloma
  • Statin

ASJC Scopus subject areas

  • Hematology

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