Effect of statins, smoking and obesity on progression of monoclonal gammopathy of undetermined significance: A case-control study

Michael A. Thompson; Robert A. Kyle; L. Joseph Melton; Matthew F. Plevak; S. Vincent Rajkumar

Effect of statins, smoking and obesity on progression of monoclonal gammopathy of undetermined significance: A case-control study

Michael A. Thompson, Robert A. Kyle, L. Joseph Melton, Matthew F. Plevak, S. Vincent Rajkumar

Research output: Contribution to journal › Article › peer-review

Abstract

Interleukin-6 (IL-6) and C-reactive protein (CRP, a surrogate marker for IL-6) are important in monoclonal gammopathy of undetermined significance (MGUS) and myeloma. Smoking and obesity may elevate CRP levels, while statins decrease CRP levels. A case-control study in 200 MGUS patients found that statin use, smoking history and obesity do not affect MGUS progression.

Original language	English (US)
Pages (from-to)	626-628
Number of pages	3
Journal	Haematologica
Volume	89
Issue number	5
State	Published - May 2004

Keywords

Hydroxymethylglutaryl-CoA reductose inhibitors
MGUS
Myeloma
Statin

ASJC Scopus subject areas

Hematology

Cite this

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title = "Effect of statins, smoking and obesity on progression of monoclonal gammopathy of undetermined significance: A case-control study",

abstract = "Interleukin-6 (IL-6) and C-reactive protein (CRP, a surrogate marker for IL-6) are important in monoclonal gammopathy of undetermined significance (MGUS) and myeloma. Smoking and obesity may elevate CRP levels, while statins decrease CRP levels. A case-control study in 200 MGUS patients found that statin use, smoking history and obesity do not affect MGUS progression.",

keywords = "Hydroxymethylglutaryl-CoA reductose inhibitors, MGUS, Myeloma, Statin",

author = "Thompson, {Michael A.} and Kyle, {Robert A.} and Melton, {L. Joseph} and Plevak, {Matthew F.} and Rajkumar, {S. Vincent}",

year = "2004",

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pages = "626--628",

journal = "Haematologica",

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T1 - Effect of statins, smoking and obesity on progression of monoclonal gammopathy of undetermined significance

T2 - A case-control study

AU - Thompson, Michael A.

AU - Kyle, Robert A.

AU - Melton, L. Joseph

AU - Plevak, Matthew F.

AU - Rajkumar, S. Vincent

PY - 2004/5

Y1 - 2004/5

N2 - Interleukin-6 (IL-6) and C-reactive protein (CRP, a surrogate marker for IL-6) are important in monoclonal gammopathy of undetermined significance (MGUS) and myeloma. Smoking and obesity may elevate CRP levels, while statins decrease CRP levels. A case-control study in 200 MGUS patients found that statin use, smoking history and obesity do not affect MGUS progression.

AB - Interleukin-6 (IL-6) and C-reactive protein (CRP, a surrogate marker for IL-6) are important in monoclonal gammopathy of undetermined significance (MGUS) and myeloma. Smoking and obesity may elevate CRP levels, while statins decrease CRP levels. A case-control study in 200 MGUS patients found that statin use, smoking history and obesity do not affect MGUS progression.

KW - Hydroxymethylglutaryl-CoA reductose inhibitors

KW - MGUS

KW - Myeloma

KW - Statin

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M3 - Article

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SN - 0390-6078

VL - 89

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JO - Haematologica

JF - Haematologica

IS - 5

ER -

Effect of statins, smoking and obesity on progression of monoclonal gammopathy of undetermined significance: A case-control study

Abstract

Keywords

ASJC Scopus subject areas

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