Effect of simulated altitude erythrocythemia in women on hemoglobin flow rate during exercise

R. J. Robertson, R. Gilcher, K. F. Metz, C. J. Caspersen, T. G. Allison, R. A. Abbott, G. S. Skrinar, J. R. Krause, P. A. Nixon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effect of simulated altitude erythrocythemia on hemoglobin flow rate and maximal O 2 uptake (V̇O(2max)) was determined for nine women sea-level residents. Test conditions included normoxia and normobaric hypoxia (16% O 2-84% N 2). Cycle tests were performed under normoxia (T 1-N) and hypoxia (T 1-H) at prereinfusion control and under hypoxia 48 h after a placebo infusion (T 2-H) and 48 h after autologous infusion of 334 ml of erythrocytes (T 3-H). Hematocrit (38.1-44.9%) and hemoglobin concentration (12.7-14.7 g·dl -1) increased from control to postreinfusion. At peak exercise, V̇O(2max) decreased from T 1-N (2.40 l·min -1) to T 1-H (2.15 l·min -1) then increased at T 3-H (2.37 l·min -1). Maximal arterial-mixed venous O 2 difference decreased from T 1-N to T 1-H and increased at T 3-H. Cardiac output (Q̇), stroke volume, heart rate, and total peripheral resistance during maximal exercise were unchanged from T 1-N through T 3-H. Hemoglobin flow rate (Hb flow) at maximum did not change from T 1-N to T 1-H but increased at T 3-H. When compared with submaximal values for T 1-N, V̇O 2 was unchanged at T 1-H and T 3-H; Q̇ increased at T 1-H and decreased at T 3-H; arterial-mixed venous O 2 difference decreased at T 1-H and increased at T 3-H; Hb flow did not change at T 1-N but increased at T 3-H. For young women, simulated altitude erythrocythemia increased peak Hb flow and decreased physiological altitude (227.8 m) but did not affect maximum cardiac output (Q̇(max)).

Original languageEnglish (US)
Pages (from-to)1644-1649
Number of pages6
JournalJournal of Applied Physiology
Volume64
Issue number4
StatePublished - 1988
Externally publishedYes

Fingerprint

Hemoglobin H
Hemoglobins
Exercise
Cardiac Output
Hematocrit
Oceans and Seas
Vascular Resistance
Stroke Volume
Erythrocytes
Heart Rate
Placebos
Hypoxia

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Robertson, R. J., Gilcher, R., Metz, K. F., Caspersen, C. J., Allison, T. G., Abbott, R. A., ... Nixon, P. A. (1988). Effect of simulated altitude erythrocythemia in women on hemoglobin flow rate during exercise. Journal of Applied Physiology, 64(4), 1644-1649.

Effect of simulated altitude erythrocythemia in women on hemoglobin flow rate during exercise. / Robertson, R. J.; Gilcher, R.; Metz, K. F.; Caspersen, C. J.; Allison, T. G.; Abbott, R. A.; Skrinar, G. S.; Krause, J. R.; Nixon, P. A.

In: Journal of Applied Physiology, Vol. 64, No. 4, 1988, p. 1644-1649.

Research output: Contribution to journalArticle

Robertson, RJ, Gilcher, R, Metz, KF, Caspersen, CJ, Allison, TG, Abbott, RA, Skrinar, GS, Krause, JR & Nixon, PA 1988, 'Effect of simulated altitude erythrocythemia in women on hemoglobin flow rate during exercise', Journal of Applied Physiology, vol. 64, no. 4, pp. 1644-1649.
Robertson RJ, Gilcher R, Metz KF, Caspersen CJ, Allison TG, Abbott RA et al. Effect of simulated altitude erythrocythemia in women on hemoglobin flow rate during exercise. Journal of Applied Physiology. 1988;64(4):1644-1649.
Robertson, R. J. ; Gilcher, R. ; Metz, K. F. ; Caspersen, C. J. ; Allison, T. G. ; Abbott, R. A. ; Skrinar, G. S. ; Krause, J. R. ; Nixon, P. A. / Effect of simulated altitude erythrocythemia in women on hemoglobin flow rate during exercise. In: Journal of Applied Physiology. 1988 ; Vol. 64, No. 4. pp. 1644-1649.
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abstract = "The effect of simulated altitude erythrocythemia on hemoglobin flow rate and maximal O 2 uptake (V̇O(2max)) was determined for nine women sea-level residents. Test conditions included normoxia and normobaric hypoxia (16{\%} O 2-84{\%} N 2). Cycle tests were performed under normoxia (T 1-N) and hypoxia (T 1-H) at prereinfusion control and under hypoxia 48 h after a placebo infusion (T 2-H) and 48 h after autologous infusion of 334 ml of erythrocytes (T 3-H). Hematocrit (38.1-44.9{\%}) and hemoglobin concentration (12.7-14.7 g·dl -1) increased from control to postreinfusion. At peak exercise, V̇O(2max) decreased from T 1-N (2.40 l·min -1) to T 1-H (2.15 l·min -1) then increased at T 3-H (2.37 l·min -1). Maximal arterial-mixed venous O 2 difference decreased from T 1-N to T 1-H and increased at T 3-H. Cardiac output (Q̇), stroke volume, heart rate, and total peripheral resistance during maximal exercise were unchanged from T 1-N through T 3-H. Hemoglobin flow rate (Hb flow) at maximum did not change from T 1-N to T 1-H but increased at T 3-H. When compared with submaximal values for T 1-N, V̇O 2 was unchanged at T 1-H and T 3-H; Q̇ increased at T 1-H and decreased at T 3-H; arterial-mixed venous O 2 difference decreased at T 1-H and increased at T 3-H; Hb flow did not change at T 1-N but increased at T 3-H. For young women, simulated altitude erythrocythemia increased peak Hb flow and decreased physiological altitude (227.8 m) but did not affect maximum cardiac output (Q̇(max)).",
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AU - Gilcher, R.

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AU - Allison, T. G.

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