Effect of simulated altitude erythrocythemia in women on hemoglobin flow rate during exercise

R. J. Robertson, R. Gilcher, K. F. Metz, C. J. Caspersen, T. G. Allison, R. A. Abbott, G. S. Skrinar, J. R. Krause, P. A. Nixon

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The effect of simulated altitude erythrocythemia on hemoglobin flow rate and maximal O2 uptake (V̇O(2max)) was determined for nine women sea-level residents. Test conditions included normoxia and normobaric hypoxia (16% O2-84% N2). Cycle tests were performed under normoxia (T1-N) and hypoxia (T1-H) at prereinfusion control and under hypoxia 48 h after a placebo infusion (T2-H) and 48 h after autologous infusion of 334 ml of erythrocytes (T3-H). Hematocrit (38.1-44.9%) and hemoglobin concentration (12.7-14.7 g·dl-1) increased from control to postreinfusion. At peak exercise, V̇O(2max) decreased from T1-N (2.40 l·min-1) to T1-H (2.15 l·min-1) then increased at T3-H (2.37 l·min-1). Maximal arterial-mixed venous O2 difference decreased from T1-N to T1-H and increased at T3-H. Cardiac output (Q̇), stroke volume, heart rate, and total peripheral resistance during maximal exercise were unchanged from T1-N through T3-H. Hemoglobin flow rate (Hb flow) at maximum did not change from T1-N to T1-H but increased at T3-H. When compared with submaximal values for T1-N, V̇O2 was unchanged at T1-H and T3-H; Q̇ increased at T1-H and decreased at T3-H; arterial-mixed venous O2 difference decreased at T1-H and increased at T3-H; Hb flow did not change at T1-N but increased at T3-H. For young women, simulated altitude erythrocythemia increased peak Hb flow and decreased physiological altitude (227.8 m) but did not affect maximum cardiac output (Q̇(max)).

Original languageEnglish (US)
Pages (from-to)1644-1649
Number of pages6
JournalJournal of applied physiology
Issue number4
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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