Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome

Joelle Bousaba; Ting Zheng; Saam Dilmaghani; Stephen Johnson; Jun Chen; Michael Camilleri

doi:10.1136/gutjnl-2022-329359

Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome

Joelle Bousaba, Ting Zheng, Saam Dilmaghani, Stephen Johnson, Jun Chen, Michael Camilleri

Research output: Contribution to journal › Review article › peer-review

Abstract

In a recent article in GUT,1 we showed that, among 194 patients with diarrhoea-predominant irritable bowel syndrome (IBS-D), 43 had altered bile acid (BA) metabolism (ABAM) (serum 7αC4>52 ng/mL). Patients with ABAM, had faster colonic transit (CT), lower α diversity and a different microbial compositional profile based on β diversity compared with IBS-D without ABAM. There were no significant differences in the stool short-chain fatty acid (SCFA) concentrations between the two groups.1 There is evidence that transit impacts gut microbiome composition and diversity.2

Original language	English (US)
Article number	gutjnl-2022-329359
Journal	Gut
DOIs	https://doi.org/10.1136/gutjnl-2022-329359
State	Accepted/In press - 2023

Keywords

DIARRHOEA
IRRITABLE BOWEL SYNDROME
SHORT CHAIN FATTY ACIDS

ASJC Scopus subject areas

Gastroenterology

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10.1136/gutjnl-2022-329359

Cite this

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title = "Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome",

abstract = "In a recent article in GUT,1 we showed that, among 194 patients with diarrhoea-predominant irritable bowel syndrome (IBS-D), 43 had altered bile acid (BA) metabolism (ABAM) (serum 7αC4>52 ng/mL). Patients with ABAM, had faster colonic transit (CT), lower α diversity and a different microbial compositional profile based on β diversity compared with IBS-D without ABAM. There were no significant differences in the stool short-chain fatty acid (SCFA) concentrations between the two groups.1 There is evidence that transit impacts gut microbiome composition and diversity.2",

keywords = "DIARRHOEA, IRRITABLE BOWEL SYNDROME, SHORT CHAIN FATTY ACIDS",

author = "Joelle Bousaba and Ting Zheng and Saam Dilmaghani and Stephen Johnson and Jun Chen and Michael Camilleri",

note = "Funding Information: This work was supported by grant R01-DK115950 from National Institutes of Health (MC). Publisher Copyright: {\textcopyright} 2023 Author(s). Published by BMJ.",

year = "2023",

doi = "10.1136/gutjnl-2022-329359",

language = "English (US)",

journal = "Gut",

issn = "0017-5749",

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T1 - Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome

AU - Bousaba, Joelle

AU - Zheng, Ting

AU - Dilmaghani, Saam

AU - Johnson, Stephen

AU - Chen, Jun

AU - Camilleri, Michael

PY - 2023

Y1 - 2023

N2 - In a recent article in GUT,1 we showed that, among 194 patients with diarrhoea-predominant irritable bowel syndrome (IBS-D), 43 had altered bile acid (BA) metabolism (ABAM) (serum 7αC4>52 ng/mL). Patients with ABAM, had faster colonic transit (CT), lower α diversity and a different microbial compositional profile based on β diversity compared with IBS-D without ABAM. There were no significant differences in the stool short-chain fatty acid (SCFA) concentrations between the two groups.1 There is evidence that transit impacts gut microbiome composition and diversity.2

AB - In a recent article in GUT,1 we showed that, among 194 patients with diarrhoea-predominant irritable bowel syndrome (IBS-D), 43 had altered bile acid (BA) metabolism (ABAM) (serum 7αC4>52 ng/mL). Patients with ABAM, had faster colonic transit (CT), lower α diversity and a different microbial compositional profile based on β diversity compared with IBS-D without ABAM. There were no significant differences in the stool short-chain fatty acid (SCFA) concentrations between the two groups.1 There is evidence that transit impacts gut microbiome composition and diversity.2

KW - DIARRHOEA

KW - IRRITABLE BOWEL SYNDROME

KW - SHORT CHAIN FATTY ACIDS

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Effect of rapid colonic transit on stool microbiome and short-chain fatty acids in diarrhoea-predominant irritable bowel syndrome

Abstract

Keywords

ASJC Scopus subject areas

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