TY - JOUR
T1 - Effect of radiocontrasts on selected membrane transport systems
AU - De Oliveira, Rubens Marona
AU - Pinheiro Da Costa, Bartira Ercília
AU - Fervenza, Fernando Custódio
AU - Wagner, Mário Bernardes
AU - D'Avila, Domingos Otavio
AU - Poli De Figueiredo, Carlos Eduardo
PY - 2005/11
Y1 - 2005/11
N2 - Background. This study was aimed at examining the effects of radiocontrast agents on selected membrane transport functions. Methods. The effect of diatrizoate sodium (DS), diatrizoate meglumine (DM), and diatrizoate compound (DC) on Na+/K+ pump activity and number, L-arginine, and choline transports were evaluated in erythrocytes of normal individuals and patients undergoing cardiac catheterization. Results. Normal individuals' erythrocytes potassium influxes were 1.50±0.35, 1.32±0.37, 1.28±0.30, and 1.01±0.25 mmol/L cell/h in control, DS, DM, and DC groups, respectively ( P = 0.004; DC vs. control). Patients exposure to Hypaque M-76® significantly diminished Na+/K+ pump activity (1.40±0.36 before, vs. 1.27±0.40 mmol/L cell/h after; P = 0.039). The number of Na+/K+ pumps was reduced (156±36 vs. 143±34 pumps/erythrocyte; P = 0.015) in presence of DS. L-arginine and choline transports changed only at high radiocontrast concentrations. Conclusion. Selective changes in erythrocytes membrane transport function take place on exposure to radiocontrasts.
AB - Background. This study was aimed at examining the effects of radiocontrast agents on selected membrane transport functions. Methods. The effect of diatrizoate sodium (DS), diatrizoate meglumine (DM), and diatrizoate compound (DC) on Na+/K+ pump activity and number, L-arginine, and choline transports were evaluated in erythrocytes of normal individuals and patients undergoing cardiac catheterization. Results. Normal individuals' erythrocytes potassium influxes were 1.50±0.35, 1.32±0.37, 1.28±0.30, and 1.01±0.25 mmol/L cell/h in control, DS, DM, and DC groups, respectively ( P = 0.004; DC vs. control). Patients exposure to Hypaque M-76® significantly diminished Na+/K+ pump activity (1.40±0.36 before, vs. 1.27±0.40 mmol/L cell/h after; P = 0.039). The number of Na+/K+ pumps was reduced (156±36 vs. 143±34 pumps/erythrocyte; P = 0.015) in presence of DS. L-arginine and choline transports changed only at high radiocontrast concentrations. Conclusion. Selective changes in erythrocytes membrane transport function take place on exposure to radiocontrasts.
KW - Choline
KW - Erythrocyte membrane
KW - L-arginine
KW - Na/K pump
KW - Radiocontrast toxicity
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U2 - 10.1080/08860220500243247
DO - 10.1080/08860220500243247
M3 - Article
C2 - 16350825
AN - SCOPUS:28644442091
SN - 0886-022X
VL - 27
SP - 727
EP - 732
JO - Renal Failure
JF - Renal Failure
IS - 6
ER -