Effect of race on the prevalence of congenital malformations among newborns in the united states

Alexander Egbe, Simon Lee, Deborah Ho, Santosh Uppu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Racial variability in certain prenatal risk factors, such as prenatal vitamin supplementation and termination of pregnancy for fetal anomaly, has altered the racial prevalence of congenital malformation (CM). Analysis of a single large representative population is required to analyze current racial differences in prevalence of CM in the United States. Method: This is a population-based crosssectional study to analyze racial differences in prevalence of CM diagnoses. We reviewed all live births in the 2008 Nationwide Inpatient Sample (NIS) database and determined birth prevalence of 55 selected CM diagnoses in Caucasians. We then calculated the relative risk of these CM diagnoses in African American, Hispanics and Asians relative to Caucasians. Result: Overall CM prevalence was 29.2 per 1,000 in a cohort of 1,048,252 live births of which 51% were Caucasians. Compared to Caucasian, risk of overall CM was lower in African Americans (RR5.9, CI .8-.9) and Hispanics (RR5.9, CI .8-.9). Risk of overall CM was similar in Caucasians and Asians. Relative to the Caucasians, African Americans had lower risk of cardiac, genitourinary, and craniofacial malformations but higher risk of musculoskeletal malformations. Hispanics had lower risk of genitourinary and gastrointestinal malformation. Asians had higher risk of craniofacial and musculoskeletal malformation. Conclusions: This is a comprehensive description of racial difference in risk of CM in the United States. Observed racial differences in risk of CM may be related to genetic susceptibilities, to cultural or social differences that could modify exposures, or to the many potential combinations between susceptibilities and exposures.

Original languageEnglish (US)
Pages (from-to)226-231
Number of pages6
JournalEthnicity and Disease
Volume25
Issue number2
StatePublished - Mar 1 2015
Externally publishedYes

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Newborn Infant
Hispanic Americans
African Americans
Live Birth
Genetic Predisposition to Disease
Vitamins
Population
Inpatients
Parturition
Databases
Pregnancy

Keywords

  • Congenital malformation
  • Epidemiology
  • Newborn
  • Race

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

Effect of race on the prevalence of congenital malformations among newborns in the united states. / Egbe, Alexander; Lee, Simon; Ho, Deborah; Uppu, Santosh.

In: Ethnicity and Disease, Vol. 25, No. 2, 01.03.2015, p. 226-231.

Research output: Contribution to journalArticle

Egbe, Alexander ; Lee, Simon ; Ho, Deborah ; Uppu, Santosh. / Effect of race on the prevalence of congenital malformations among newborns in the united states. In: Ethnicity and Disease. 2015 ; Vol. 25, No. 2. pp. 226-231.
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