Effect of post-remission chemotherapy preceding allogeneic hematopoietic cell transplant in patients with acute myeloid leukemia in first remission

Lisa Sproat, Brian Bolwell, Lisa Rybicki, Shawnda Tench, Josephine Chan, Matt Kalaycio, Robert Dean, Ronald Sobecks, Brad Pohlman, Steven Andresen, John Sweetenham, Edward Copelan

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8 Scopus citations

Abstract

Patients with acute myeloid leukemia (AML) with intermediate or high risk cytogenetics are often considered for allogeneic hematopoietic stem cell transplant (AHSCT) in first remission. Between attainment of remission and AHSCT, post-remission chemotherapy is frequently administered, though there is no evidence for its effectiveness. This study was performed to determine the impact of post-remission chemotherapy on outcome after AHSCT. A subset analysis was performed to determine whether the influence of post-remission chemotherapy might be different in those with intermediate compared to high risk cytogenetics. There was no significant difference in relapse mortality (RM) (p = 0.70), non-relapse mortality (NRM) (p = 0.12), or survival (OS) (p = 0.15) between post-remission chemotherapy groups. There was no difference in RM, NRM, or OS between cytogenetic groups according to whether they received post-remission chemotherapy. No differential effect between intermediate and high risk cytogenetics was detected (RM, p = 0.80; NRM, p = 0.23; OS, p = 0.26). These data do not show a benefit of post-remission chemotherapy before AHSCT.

Original languageEnglish (US)
Pages (from-to)1699-1704
Number of pages6
JournalLeukemia and Lymphoma
Volume51
Issue number9
DOIs
StatePublished - Sep 2010
Externally publishedYes

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Keywords

  • Acute myeloid leukemia
  • hematopoietic stem cell transplant
  • post-remission consolidation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Sproat, L., Bolwell, B., Rybicki, L., Tench, S., Chan, J., Kalaycio, M., Dean, R., Sobecks, R., Pohlman, B., Andresen, S., Sweetenham, J., & Copelan, E. (2010). Effect of post-remission chemotherapy preceding allogeneic hematopoietic cell transplant in patients with acute myeloid leukemia in first remission. Leukemia and Lymphoma, 51(9), 1699-1704. https://doi.org/10.3109/10428194.2010.500431