Effect of phagocytosis and Fc receptor occupancy on complement dependent neutrophil chemotaxis

Neil Elliot Kay, T. F. Bumol, S. D. Douglas

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Neutrophil migration was assessed following cell interaction with IgG or after phagocytosis of antibody-coated EA or latex. The migration of these neutrophil preparations was markedly impaired as studied in an agarose medium with zymosan activated serum (ZAS) as the chemoattractant. Neutrophils which had interacted with EA retained some capacity for directed migration toward synthetic tripeptides and E. coli filtrate. Rosette formation with EA(IgM)C3 did not impair cell movement. The reduced cell migration observed after immune or nonimmune ingestion was reversible following a prolonged incubation period. The results suggest that phagocytosis or Fc receptor occupancy transiently blocks the ability of neutrophils to migrate.

Original languageEnglish (US)
Pages (from-to)850-856
Number of pages7
JournalJournal of Laboratory and Clinical Medicine
Volume91
Issue number5
StatePublished - 1978
Externally publishedYes

Fingerprint

Zymosan
Fc Receptors
Chemotactic Factors
Latex
Chemotaxis
Sepharose
Escherichia coli
Immunoglobulin M
Neutrophils
Immunoglobulin G
Cells
Antibodies
Cell Movement
Rosette Formation
Aptitude
Phagocytosis
Cell Communication
Eating
phagocytosis receptor
Serum

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Effect of phagocytosis and Fc receptor occupancy on complement dependent neutrophil chemotaxis. / Kay, Neil Elliot; Bumol, T. F.; Douglas, S. D.

In: Journal of Laboratory and Clinical Medicine, Vol. 91, No. 5, 1978, p. 850-856.

Research output: Contribution to journalArticle

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