Neutrophil migration was assessed following cell interaction with IgG or after phagocytosis of antibody-coated EA or latex. The migration of these neutrophil preparations was markedly impaired as studied in an agarose medium with zymosan activated serum (ZAS) as the chemoattractant. Neutrophils which had interacted with EA retained some capacity for directed migration toward synthetic tripeptides and E. coli filtrate. Rosette formation with EA(IgM)C3 did not impair cell movement. The reduced cell migration observed after immune or nonimmune ingestion was reversible following a prolonged incubation period. The results suggest that phagocytosis or Fc receptor occupancy transiently blocks the ability of neutrophils to migrate.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Laboratory and Clinical Medicine|
|State||Published - Dec 1 1978|
ASJC Scopus subject areas
- Pathology and Forensic Medicine