Effect of parenteral administration of short-chain triglycerides on leucine metabolism

J. W. Bailey, J. M. Miles, M. W. Haymond

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The present studies investigated the effects of intravenous administration of the short-chain triglyceride triacetin on leucine metabolism in dogs. Animals received infusions of triacetin at 1.0 x estimated resting energy expenditure (REE), hyperenergetic triacetin at 1.5 x REE, glycerol, or saline during infusion of [1-14C]leucine. During both triacetin infusions, plasma α-ketoisocaproate concentrations increased (P < 0.05). During triacetin infusion at 1.5 REE, the plasma leucine concentration decreased (P < 0.05) and leucine rate of appearance decreased by ≃19% (P < 0.05); this was significantly greater than the changes that occurred during triacetin at 1.0 x REE and glycerol (P < 0.05). There was no difference in leucine oxidation between the dogs given triacetin at 1.0 x REE and control groups, whereas leucine oxidation decreased by 53% during triacetin infusion at 1.5 x REE (P < 0.05). Nonoxidative leucine disappearance, an indicator of protein synthesis, did not change in any of the studies. These results indicate that triacetin has effects on leucine metabolism similar to those previously reported with long-chain triglyceride emulsions. Because of its water solubility, lack of toxicity, and favorable effects on protein metabolism, further studies are warranted regarding the use of triacetin as a parenteral nutrient.

Original languageEnglish (US)
Pages (from-to)912-916
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume58
Issue number6
StatePublished - 1993

Fingerprint

Triacetin
triacetin
Leucine
leucine
Triglycerides
resting energy expenditure
triacylglycerols
metabolism
Energy Metabolism
Glycerol
glycerol
Dogs
oxidation
long chain triacylglycerols
dogs
water solubility
Emulsions
protein metabolism
intravenous injection
Intravenous Administration

Keywords

  • acetate
  • dogs
  • fatty acid
  • leucine
  • lipid metabolism
  • parenteral nutrition
  • Triacetin

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Effect of parenteral administration of short-chain triglycerides on leucine metabolism. / Bailey, J. W.; Miles, J. M.; Haymond, M. W.

In: American Journal of Clinical Nutrition, Vol. 58, No. 6, 1993, p. 912-916.

Research output: Contribution to journalArticle

Bailey, J. W. ; Miles, J. M. ; Haymond, M. W. / Effect of parenteral administration of short-chain triglycerides on leucine metabolism. In: American Journal of Clinical Nutrition. 1993 ; Vol. 58, No. 6. pp. 912-916.
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