Effect of nephrectomy for retroperitoneal sarcoma on post-operative renal function

Daniel B. Kim, Richard Gray, Zhuo Li, Nabil Wasif, Sanjay P. Bagaria

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Background and Objectives: Surgical resection of retroperitoneal sarcomas (RPS) often involves removal of the ipsilateral kidney. We evaluated the long-term post-operative renal function in patients who underwent a nephrectomy as part of their en-bloc resection of RPS. Methods: Retrospective review of an institutional database identified RPS patients who underwent nephrectomy for curative intent from 1990 to 2014. The primary outcome measured was chronic kidney disease (CKD) calculated by the glomerular filtration rate (GFR). Results: Of the 47 patients in our study, 19 (40%), 18 (38%), and 10 (21%) patients had a preoperative CKD stage 1, 2, and 3, respectively. The GFR decreased by an average of 33.4 mL/min/1.73 m2 with 66% of patients demonstrating mild progression of their renal impairment. Only three (6%) patients progressed to CKD stage 4 or 5, one of which required life-long dialysis. Conclusion: Nephrectomy as part of an en-bloc resection is associated with a decrease in GFR that is not clinically significant. Fear of kidney failure should not prevent a surgeon from performing a nephrectomy in the treatment of RPS.

Original languageEnglish (US)
Pages (from-to)425-429
Number of pages5
JournalJournal of Surgical Oncology
Issue number3
StatePublished - Mar 1 2018


  • GFR
  • chronic kidney disease
  • nephrectomy
  • renal function
  • retroperitoneal sarcoma

ASJC Scopus subject areas

  • Surgery
  • Oncology


Dive into the research topics of 'Effect of nephrectomy for retroperitoneal sarcoma on post-operative renal function'. Together they form a unique fingerprint.

Cite this