Effect of motion on the ADC quantification accuracy of whole-body DWIBS

Alan J. Stone, Jacinta E. Browne, Brian Lennon, James F. Meaney, Andrew J. Fagan

Research output: Contribution to journalArticlepeer-review

Abstract

Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume25
Issue number4
DOIs
StatePublished - Aug 2012

Keywords

  • Apparent diffusion coefficient
  • Diffusion-weighted imaging
  • DWIBS
  • Liver Free breathing
  • Motion phantom

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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