Effect of motion on the ADC quantification accuracy of whole-body DWIBS

Alan J. Stone; Jacinta E. Browne; Brian Lennon; James F. Meaney; Andrew J. Fagan

doi:10.1007/s10334-012-0311-1

Effect of motion on the ADC quantification accuracy of whole-body DWIBS

Alan J. Stone, Jacinta E. Browne, Brian Lennon, James F. Meaney, Andrew J. Fagan

Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.

Original language	English (US)
Pages (from-to)	263-266
Number of pages	4
Journal	Magnetic Resonance Materials in Physics, Biology and Medicine
Volume	25
Issue number	4
DOIs	https://doi.org/10.1007/s10334-012-0311-1
State	Published - Aug 2012

Keywords

Apparent diffusion coefficient
DWIBS
Diffusion-weighted imaging
Liver Free breathing
Motion phantom

ASJC Scopus subject areas

Biophysics
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1007/s10334-012-0311-1

Cite this

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title = "Effect of motion on the ADC quantification accuracy of whole-body DWIBS",

abstract = "Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.",

keywords = "Apparent diffusion coefficient, DWIBS, Diffusion-weighted imaging, Liver Free breathing, Motion phantom",

author = "Stone, {Alan J.} and Browne, {Jacinta E.} and Brian Lennon and Meaney, {James F.} and Fagan, {Andrew J.}",

note = "Funding Information: Acknowledgments The work was financially supported by an institutional grant from the Health Research Board (HRB) Ireland.",

year = "2012",

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doi = "10.1007/s10334-012-0311-1",

language = "English (US)",

volume = "25",

pages = "263--266",

journal = "Magnetic Resonance Materials in Physics, Biology and Medicine",

issn = "0968-5243",

publisher = "Springer Verlag",

number = "4",

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TY - JOUR

T1 - Effect of motion on the ADC quantification accuracy of whole-body DWIBS

AU - Stone, Alan J.

AU - Browne, Jacinta E.

AU - Lennon, Brian

AU - Meaney, James F.

AU - Fagan, Andrew J.

N1 - Funding Information: Acknowledgments The work was financially supported by an institutional grant from the Health Research Board (HRB) Ireland.

PY - 2012/8

Y1 - 2012/8

N2 - Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.

AB - Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.

KW - Apparent diffusion coefficient

KW - DWIBS

KW - Diffusion-weighted imaging

KW - Liver Free breathing

KW - Motion phantom

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Effect of motion on the ADC quantification accuracy of whole-body DWIBS

Abstract

Keywords

ASJC Scopus subject areas

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