Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome

Annemie Deiteren, Michael Camilleri, Duane Burton, Sanna McKinzie, Archana Rao, Alan R. Zinsmeister

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Postprandial symptoms in irritable bowel syndrome (IBS) have been associated with increased bowel contractility. Aim: To compare ileocolonic and colonic responses to feeding in health and IBS. Methods: We prospectively analyzed data from separate research trials in 122 IBS patients and 41 healthy volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling [CF]3h) and immediately after (CF4h) a standard lunch at 3 h 45 min, and 2 h thereafter. The colonic geometric center (GC) was calculated 2 h (GC6h) after lunch ingested at 4 h (GC4h) and directly after (GC8h) a standard dinner ingested at 7 h 45 min. Results: ICT immediately after eating was higher in IBS diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 ± 2.4 vs. 17.5 ± 2.8%, P = 0.059). ICT 2 h after lunch was similar between groups (P = 0.55). There was significant overall group differences in colonic transit 2 h post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; GC6-GC4, Δ0.29 ± 0.08) patients versus healthy volunteers (Δ0.56 ± 0.12 GC units). Conclusions: After feeding, ICT is increased in IBS-D, whereas colonic transit is blunted in IBS-C.

Original languageEnglish (US)
Pages (from-to)384-391
Number of pages8
JournalDigestive Diseases and Sciences
Volume55
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Irritable Bowel Syndrome
Meals
Eating
Lunch
Health
Healthy Volunteers
Constipation
Diarrhea
Research

Keywords

  • Colonic
  • Gastrocolic reflex
  • Gastroileal reflex
  • Ileocolonic
  • Response to food

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

Cite this

Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome. / Deiteren, Annemie; Camilleri, Michael; Burton, Duane; McKinzie, Sanna; Rao, Archana; Zinsmeister, Alan R.

In: Digestive Diseases and Sciences, Vol. 55, No. 2, 02.2010, p. 384-391.

Research output: Contribution to journalArticle

Deiteren, Annemie ; Camilleri, Michael ; Burton, Duane ; McKinzie, Sanna ; Rao, Archana ; Zinsmeister, Alan R. / Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome. In: Digestive Diseases and Sciences. 2010 ; Vol. 55, No. 2. pp. 384-391.
@article{92cd9cc78c5246138a88c0453fc26a4f,
title = "Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome",
abstract = "Background: Postprandial symptoms in irritable bowel syndrome (IBS) have been associated with increased bowel contractility. Aim: To compare ileocolonic and colonic responses to feeding in health and IBS. Methods: We prospectively analyzed data from separate research trials in 122 IBS patients and 41 healthy volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling [CF]3h) and immediately after (CF4h) a standard lunch at 3 h 45 min, and 2 h thereafter. The colonic geometric center (GC) was calculated 2 h (GC6h) after lunch ingested at 4 h (GC4h) and directly after (GC8h) a standard dinner ingested at 7 h 45 min. Results: ICT immediately after eating was higher in IBS diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 ± 2.4 vs. 17.5 ± 2.8{\%}, P = 0.059). ICT 2 h after lunch was similar between groups (P = 0.55). There was significant overall group differences in colonic transit 2 h post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; GC6-GC4, Δ0.29 ± 0.08) patients versus healthy volunteers (Δ0.56 ± 0.12 GC units). Conclusions: After feeding, ICT is increased in IBS-D, whereas colonic transit is blunted in IBS-C.",
keywords = "Colonic, Gastrocolic reflex, Gastroileal reflex, Ileocolonic, Response to food",
author = "Annemie Deiteren and Michael Camilleri and Duane Burton and Sanna McKinzie and Archana Rao and Zinsmeister, {Alan R.}",
year = "2010",
month = "2",
doi = "10.1007/s10620-009-1041-8",
language = "English (US)",
volume = "55",
pages = "384--391",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome

AU - Deiteren, Annemie

AU - Camilleri, Michael

AU - Burton, Duane

AU - McKinzie, Sanna

AU - Rao, Archana

AU - Zinsmeister, Alan R.

PY - 2010/2

Y1 - 2010/2

N2 - Background: Postprandial symptoms in irritable bowel syndrome (IBS) have been associated with increased bowel contractility. Aim: To compare ileocolonic and colonic responses to feeding in health and IBS. Methods: We prospectively analyzed data from separate research trials in 122 IBS patients and 41 healthy volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling [CF]3h) and immediately after (CF4h) a standard lunch at 3 h 45 min, and 2 h thereafter. The colonic geometric center (GC) was calculated 2 h (GC6h) after lunch ingested at 4 h (GC4h) and directly after (GC8h) a standard dinner ingested at 7 h 45 min. Results: ICT immediately after eating was higher in IBS diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 ± 2.4 vs. 17.5 ± 2.8%, P = 0.059). ICT 2 h after lunch was similar between groups (P = 0.55). There was significant overall group differences in colonic transit 2 h post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; GC6-GC4, Δ0.29 ± 0.08) patients versus healthy volunteers (Δ0.56 ± 0.12 GC units). Conclusions: After feeding, ICT is increased in IBS-D, whereas colonic transit is blunted in IBS-C.

AB - Background: Postprandial symptoms in irritable bowel syndrome (IBS) have been associated with increased bowel contractility. Aim: To compare ileocolonic and colonic responses to feeding in health and IBS. Methods: We prospectively analyzed data from separate research trials in 122 IBS patients and 41 healthy volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling [CF]3h) and immediately after (CF4h) a standard lunch at 3 h 45 min, and 2 h thereafter. The colonic geometric center (GC) was calculated 2 h (GC6h) after lunch ingested at 4 h (GC4h) and directly after (GC8h) a standard dinner ingested at 7 h 45 min. Results: ICT immediately after eating was higher in IBS diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 ± 2.4 vs. 17.5 ± 2.8%, P = 0.059). ICT 2 h after lunch was similar between groups (P = 0.55). There was significant overall group differences in colonic transit 2 h post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; GC6-GC4, Δ0.29 ± 0.08) patients versus healthy volunteers (Δ0.56 ± 0.12 GC units). Conclusions: After feeding, ICT is increased in IBS-D, whereas colonic transit is blunted in IBS-C.

KW - Colonic

KW - Gastrocolic reflex

KW - Gastroileal reflex

KW - Ileocolonic

KW - Response to food

UR - http://www.scopus.com/inward/record.url?scp=76849093336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76849093336&partnerID=8YFLogxK

U2 - 10.1007/s10620-009-1041-8

DO - 10.1007/s10620-009-1041-8

M3 - Article

C2 - 19949866

AN - SCOPUS:76849093336

VL - 55

SP - 384

EP - 391

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 2

ER -