Effect of maternal and infant covariates on sibship correlation in birth weight

T. H. Beaty, Ping Yang, A. Munoz, M. J. Khoury

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Birth weight on 12,644 singleton infants from 6,196 sibships born in Maryland between 1980 and 1984 were used to estimate the effects of nine maternal and infant covariates on the sibship correlation in birth weight. Assuming a homogeneous correlation across all families, the estimated intraclass correlation was 0.4664 ± 0.0099). This high sibship correlation makes it possible to predict, with reasonable accuracy, the birth weight of a child given information on previous sibs, as well as covariates on the mother and/or infant pertinent to a given pregnancy. The reduction in variance associated with incorporating information on the nine covariates used here was approximately equal to that obtained by conditioning on a single previous sib. Testing for heterogeneity in correlation among different groups of families showed that a crude measure of parity (first live birth vs. other), time between births, mother's marital status, and maternal age at the birth of the last child significantly influenced the sibship correlation in birth weight.

Original languageEnglish (US)
Pages (from-to)241-253
Number of pages13
JournalGenetic Epidemiology
Volume5
Issue number4
StatePublished - 1988
Externally publishedYes

Fingerprint

Birth Weight
Mothers
Parturition
Birth Order
Maternal Age
Marital Status
Live Birth
Parity
Pregnancy

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Cite this

Effect of maternal and infant covariates on sibship correlation in birth weight. / Beaty, T. H.; Yang, Ping; Munoz, A.; Khoury, M. J.

In: Genetic Epidemiology, Vol. 5, No. 4, 1988, p. 241-253.

Research output: Contribution to journalArticle

Beaty, TH, Yang, P, Munoz, A & Khoury, MJ 1988, 'Effect of maternal and infant covariates on sibship correlation in birth weight', Genetic Epidemiology, vol. 5, no. 4, pp. 241-253.
Beaty, T. H. ; Yang, Ping ; Munoz, A. ; Khoury, M. J. / Effect of maternal and infant covariates on sibship correlation in birth weight. In: Genetic Epidemiology. 1988 ; Vol. 5, No. 4. pp. 241-253.
@article{f6a7a8e429234946a7c5b737a9b98d82,
title = "Effect of maternal and infant covariates on sibship correlation in birth weight",
abstract = "Birth weight on 12,644 singleton infants from 6,196 sibships born in Maryland between 1980 and 1984 were used to estimate the effects of nine maternal and infant covariates on the sibship correlation in birth weight. Assuming a homogeneous correlation across all families, the estimated intraclass correlation was 0.4664 ± 0.0099). This high sibship correlation makes it possible to predict, with reasonable accuracy, the birth weight of a child given information on previous sibs, as well as covariates on the mother and/or infant pertinent to a given pregnancy. The reduction in variance associated with incorporating information on the nine covariates used here was approximately equal to that obtained by conditioning on a single previous sib. Testing for heterogeneity in correlation among different groups of families showed that a crude measure of parity (first live birth vs. other), time between births, mother's marital status, and maternal age at the birth of the last child significantly influenced the sibship correlation in birth weight.",
author = "Beaty, {T. H.} and Ping Yang and A. Munoz and Khoury, {M. J.}",
year = "1988",
language = "English (US)",
volume = "5",
pages = "241--253",
journal = "Genetic Epidemiology",
issn = "0741-0395",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Effect of maternal and infant covariates on sibship correlation in birth weight

AU - Beaty, T. H.

AU - Yang, Ping

AU - Munoz, A.

AU - Khoury, M. J.

PY - 1988

Y1 - 1988

N2 - Birth weight on 12,644 singleton infants from 6,196 sibships born in Maryland between 1980 and 1984 were used to estimate the effects of nine maternal and infant covariates on the sibship correlation in birth weight. Assuming a homogeneous correlation across all families, the estimated intraclass correlation was 0.4664 ± 0.0099). This high sibship correlation makes it possible to predict, with reasonable accuracy, the birth weight of a child given information on previous sibs, as well as covariates on the mother and/or infant pertinent to a given pregnancy. The reduction in variance associated with incorporating information on the nine covariates used here was approximately equal to that obtained by conditioning on a single previous sib. Testing for heterogeneity in correlation among different groups of families showed that a crude measure of parity (first live birth vs. other), time between births, mother's marital status, and maternal age at the birth of the last child significantly influenced the sibship correlation in birth weight.

AB - Birth weight on 12,644 singleton infants from 6,196 sibships born in Maryland between 1980 and 1984 were used to estimate the effects of nine maternal and infant covariates on the sibship correlation in birth weight. Assuming a homogeneous correlation across all families, the estimated intraclass correlation was 0.4664 ± 0.0099). This high sibship correlation makes it possible to predict, with reasonable accuracy, the birth weight of a child given information on previous sibs, as well as covariates on the mother and/or infant pertinent to a given pregnancy. The reduction in variance associated with incorporating information on the nine covariates used here was approximately equal to that obtained by conditioning on a single previous sib. Testing for heterogeneity in correlation among different groups of families showed that a crude measure of parity (first live birth vs. other), time between births, mother's marital status, and maternal age at the birth of the last child significantly influenced the sibship correlation in birth weight.

UR - http://www.scopus.com/inward/record.url?scp=0023721564&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023721564&partnerID=8YFLogxK

M3 - Article

C2 - 3169527

AN - SCOPUS:0023721564

VL - 5

SP - 241

EP - 253

JO - Genetic Epidemiology

JF - Genetic Epidemiology

SN - 0741-0395

IS - 4

ER -