Effect of Lymphatic Mapping on Diagnosis and Treatment of Patients with T1a, T1b Favorable Breast Cancer

James W Jakub, Mark D. Ebert, Nils M. Diaz, Alan Cantor, Douglas S. Reintgen, Elisabeth L. Dupont, Alan R. Shons, Charles E. Cox, Kirby I. Bland, Kelly M. McMasters, Edward M. Copeland

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the incidence of nodal metastasis in a consecutive series of patients treated at the authors' institution with highly selective criteria, and to determine the impact that lymphatic mapping and sentinel node biopsy have on the detection of nodal metastases in this carefully selected patient population. Methods: Study patients were selected from the 7,750 breast cancer patients entered into the authors' database from April 1989 to August 2001, based on the following criteria: nonpalpable, T1a and T1b, non-high nuclear grade tumors, without lymphovascular invasion. Results: Of the 7,750 patients in the database 1,327 (17%) were found to have T1a and T1b lesions. Three hundred eighty-nine patients were confirmed to meet all four selection criteria. This represents 5% (389/7,750) of the authors' breast cancer patients and 29.3% (389/1,327) of the authors' T1a/T1b tumors. One hundred sixty patients were diagnosed before routine use of lymphatic mapping, and only one patient had a positive axillary lymph node. Two hundred twenty-nine patients underwent lymphatic mapping and sentinel lymph node biopsy, and 10 had a positive axillary lymph node. The difference in proportions of nodal positivity between the mapped and unmapped patients was significant. Conclusions: This study clearly demonstrates the ability of lymphatic mapping and a more detailed examination of the sentinel node to increase the accuracy of axillary staging. It has been argued that this highly selected group of breast cancer patients possessing retrospectively identified "favorable" characteristics does not require axillary staging. This select population represents only 5% of breast cancer patients in this series, and the authors do not believe they can be accurately identified pre-operatively. Therefore, the authors strongly argue for evaluation of the axillary nodal status by lymphatic mapping.

Original languageEnglish (US)
Pages (from-to)838-843
Number of pages6
JournalAnnals of Surgery
Volume237
Issue number6
DOIs
StatePublished - Jun 2003
Externally publishedYes

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Breast Neoplasms
Therapeutics
Lymph Nodes
Databases
Neoplasm Metastasis
Sentinel Lymph Node Biopsy
Patient Selection
Population
Neoplasms
Biopsy
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Jakub, J. W., Ebert, M. D., Diaz, N. M., Cantor, A., Reintgen, D. S., Dupont, E. L., ... Copeland, E. M. (2003). Effect of Lymphatic Mapping on Diagnosis and Treatment of Patients with T1a, T1b Favorable Breast Cancer. Annals of Surgery, 237(6), 838-843. https://doi.org/10.1097/00000658-200306000-00012

Effect of Lymphatic Mapping on Diagnosis and Treatment of Patients with T1a, T1b Favorable Breast Cancer. / Jakub, James W; Ebert, Mark D.; Diaz, Nils M.; Cantor, Alan; Reintgen, Douglas S.; Dupont, Elisabeth L.; Shons, Alan R.; Cox, Charles E.; Bland, Kirby I.; McMasters, Kelly M.; Copeland, Edward M.

In: Annals of Surgery, Vol. 237, No. 6, 06.2003, p. 838-843.

Research output: Contribution to journalArticle

Jakub, JW, Ebert, MD, Diaz, NM, Cantor, A, Reintgen, DS, Dupont, EL, Shons, AR, Cox, CE, Bland, KI, McMasters, KM & Copeland, EM 2003, 'Effect of Lymphatic Mapping on Diagnosis and Treatment of Patients with T1a, T1b Favorable Breast Cancer', Annals of Surgery, vol. 237, no. 6, pp. 838-843. https://doi.org/10.1097/00000658-200306000-00012
Jakub, James W ; Ebert, Mark D. ; Diaz, Nils M. ; Cantor, Alan ; Reintgen, Douglas S. ; Dupont, Elisabeth L. ; Shons, Alan R. ; Cox, Charles E. ; Bland, Kirby I. ; McMasters, Kelly M. ; Copeland, Edward M. / Effect of Lymphatic Mapping on Diagnosis and Treatment of Patients with T1a, T1b Favorable Breast Cancer. In: Annals of Surgery. 2003 ; Vol. 237, No. 6. pp. 838-843.
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T1 - Effect of Lymphatic Mapping on Diagnosis and Treatment of Patients with T1a, T1b Favorable Breast Cancer

AU - Jakub, James W

AU - Ebert, Mark D.

AU - Diaz, Nils M.

AU - Cantor, Alan

AU - Reintgen, Douglas S.

AU - Dupont, Elisabeth L.

AU - Shons, Alan R.

AU - Cox, Charles E.

AU - Bland, Kirby I.

AU - McMasters, Kelly M.

AU - Copeland, Edward M.

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N2 - Objective: To investigate the incidence of nodal metastasis in a consecutive series of patients treated at the authors' institution with highly selective criteria, and to determine the impact that lymphatic mapping and sentinel node biopsy have on the detection of nodal metastases in this carefully selected patient population. Methods: Study patients were selected from the 7,750 breast cancer patients entered into the authors' database from April 1989 to August 2001, based on the following criteria: nonpalpable, T1a and T1b, non-high nuclear grade tumors, without lymphovascular invasion. Results: Of the 7,750 patients in the database 1,327 (17%) were found to have T1a and T1b lesions. Three hundred eighty-nine patients were confirmed to meet all four selection criteria. This represents 5% (389/7,750) of the authors' breast cancer patients and 29.3% (389/1,327) of the authors' T1a/T1b tumors. One hundred sixty patients were diagnosed before routine use of lymphatic mapping, and only one patient had a positive axillary lymph node. Two hundred twenty-nine patients underwent lymphatic mapping and sentinel lymph node biopsy, and 10 had a positive axillary lymph node. The difference in proportions of nodal positivity between the mapped and unmapped patients was significant. Conclusions: This study clearly demonstrates the ability of lymphatic mapping and a more detailed examination of the sentinel node to increase the accuracy of axillary staging. It has been argued that this highly selected group of breast cancer patients possessing retrospectively identified "favorable" characteristics does not require axillary staging. This select population represents only 5% of breast cancer patients in this series, and the authors do not believe they can be accurately identified pre-operatively. Therefore, the authors strongly argue for evaluation of the axillary nodal status by lymphatic mapping.

AB - Objective: To investigate the incidence of nodal metastasis in a consecutive series of patients treated at the authors' institution with highly selective criteria, and to determine the impact that lymphatic mapping and sentinel node biopsy have on the detection of nodal metastases in this carefully selected patient population. Methods: Study patients were selected from the 7,750 breast cancer patients entered into the authors' database from April 1989 to August 2001, based on the following criteria: nonpalpable, T1a and T1b, non-high nuclear grade tumors, without lymphovascular invasion. Results: Of the 7,750 patients in the database 1,327 (17%) were found to have T1a and T1b lesions. Three hundred eighty-nine patients were confirmed to meet all four selection criteria. This represents 5% (389/7,750) of the authors' breast cancer patients and 29.3% (389/1,327) of the authors' T1a/T1b tumors. One hundred sixty patients were diagnosed before routine use of lymphatic mapping, and only one patient had a positive axillary lymph node. Two hundred twenty-nine patients underwent lymphatic mapping and sentinel lymph node biopsy, and 10 had a positive axillary lymph node. The difference in proportions of nodal positivity between the mapped and unmapped patients was significant. Conclusions: This study clearly demonstrates the ability of lymphatic mapping and a more detailed examination of the sentinel node to increase the accuracy of axillary staging. It has been argued that this highly selected group of breast cancer patients possessing retrospectively identified "favorable" characteristics does not require axillary staging. This select population represents only 5% of breast cancer patients in this series, and the authors do not believe they can be accurately identified pre-operatively. Therefore, the authors strongly argue for evaluation of the axillary nodal status by lymphatic mapping.

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