Effect of long-term hormone replacement therapy on coronary endothelial function in postmenopausal women

Sean C. Halligan, Blaithnead Murtagh, Ryan J. Lennon, Geralyn M. Pumper, Verghese Mathew, Stuart T. Higano, Amir Lerman

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Abstract

OBJECTIVES: To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function. PATIENTS AND METHODS: Women undergoing coronary physiology studies for chest pain at the Mayo Clinic in Rochester, Minn, between December 1992 and April 2002 underwent assessment of coronary endothelium-independent and -dependent function with intraeoronary administration of adenosine and acetylcholine, respectively. The coronary diameters, coronary blood flows, and coronary velocity reserves were measured. RESULTS: A total of 270 women (89 premenopausal and 181 postmenopausal) participated in the study. Endothelium-dependent coronary blood flow change (baseline to peak flow) in response to acetylchollne (10-6, 10-5, and 10-4 mol/L) was lower in postmenopausal women compared with premenopausal women (39.7% vs 72.9%, P=.03). There was no significant difference between the postmenopausal women receiving and not receiving HRT with regard to percent change in coronary diameter (-21.8% vs -13.9%, P=.15), percent change in coronary blood flow (37.3% vs 42.7%, Pt.74), or coronary velocity reserve (2.7 vs 2.7, P=.82). CONCLUSION: This study shows that the postmenopausal state is associated with a greater abnormality in coronary endothelial function at the level of the microcirculation. Moreover, HRT status was not associated with an improvement in coronary endothelial function in postmenopausal woman.

Original languageEnglish (US)
Pages (from-to)1514-1520
Number of pages7
JournalMayo Clinic Proceedings
Volume79
Issue number12
StatePublished - 2004

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Hormone Replacement Therapy
Endothelium
Blood Flow Velocity
Microcirculation
Chest Pain
Adenosine
Acetylcholine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Halligan, S. C., Murtagh, B., Lennon, R. J., Pumper, G. M., Mathew, V., Higano, S. T., & Lerman, A. (2004). Effect of long-term hormone replacement therapy on coronary endothelial function in postmenopausal women. Mayo Clinic Proceedings, 79(12), 1514-1520.

Effect of long-term hormone replacement therapy on coronary endothelial function in postmenopausal women. / Halligan, Sean C.; Murtagh, Blaithnead; Lennon, Ryan J.; Pumper, Geralyn M.; Mathew, Verghese; Higano, Stuart T.; Lerman, Amir.

In: Mayo Clinic Proceedings, Vol. 79, No. 12, 2004, p. 1514-1520.

Research output: Contribution to journalArticle

Halligan, SC, Murtagh, B, Lennon, RJ, Pumper, GM, Mathew, V, Higano, ST & Lerman, A 2004, 'Effect of long-term hormone replacement therapy on coronary endothelial function in postmenopausal women', Mayo Clinic Proceedings, vol. 79, no. 12, pp. 1514-1520.
Halligan SC, Murtagh B, Lennon RJ, Pumper GM, Mathew V, Higano ST et al. Effect of long-term hormone replacement therapy on coronary endothelial function in postmenopausal women. Mayo Clinic Proceedings. 2004;79(12):1514-1520.
Halligan, Sean C. ; Murtagh, Blaithnead ; Lennon, Ryan J. ; Pumper, Geralyn M. ; Mathew, Verghese ; Higano, Stuart T. ; Lerman, Amir. / Effect of long-term hormone replacement therapy on coronary endothelial function in postmenopausal women. In: Mayo Clinic Proceedings. 2004 ; Vol. 79, No. 12. pp. 1514-1520.
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abstract = "OBJECTIVES: To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function. PATIENTS AND METHODS: Women undergoing coronary physiology studies for chest pain at the Mayo Clinic in Rochester, Minn, between December 1992 and April 2002 underwent assessment of coronary endothelium-independent and -dependent function with intraeoronary administration of adenosine and acetylcholine, respectively. The coronary diameters, coronary blood flows, and coronary velocity reserves were measured. RESULTS: A total of 270 women (89 premenopausal and 181 postmenopausal) participated in the study. Endothelium-dependent coronary blood flow change (baseline to peak flow) in response to acetylchollne (10-6, 10-5, and 10-4 mol/L) was lower in postmenopausal women compared with premenopausal women (39.7{\%} vs 72.9{\%}, P=.03). There was no significant difference between the postmenopausal women receiving and not receiving HRT with regard to percent change in coronary diameter (-21.8{\%} vs -13.9{\%}, P=.15), percent change in coronary blood flow (37.3{\%} vs 42.7{\%}, Pt.74), or coronary velocity reserve (2.7 vs 2.7, P=.82). CONCLUSION: This study shows that the postmenopausal state is associated with a greater abnormality in coronary endothelial function at the level of the microcirculation. Moreover, HRT status was not associated with an improvement in coronary endothelial function in postmenopausal woman.",
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AB - OBJECTIVES: To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function. PATIENTS AND METHODS: Women undergoing coronary physiology studies for chest pain at the Mayo Clinic in Rochester, Minn, between December 1992 and April 2002 underwent assessment of coronary endothelium-independent and -dependent function with intraeoronary administration of adenosine and acetylcholine, respectively. The coronary diameters, coronary blood flows, and coronary velocity reserves were measured. RESULTS: A total of 270 women (89 premenopausal and 181 postmenopausal) participated in the study. Endothelium-dependent coronary blood flow change (baseline to peak flow) in response to acetylchollne (10-6, 10-5, and 10-4 mol/L) was lower in postmenopausal women compared with premenopausal women (39.7% vs 72.9%, P=.03). There was no significant difference between the postmenopausal women receiving and not receiving HRT with regard to percent change in coronary diameter (-21.8% vs -13.9%, P=.15), percent change in coronary blood flow (37.3% vs 42.7%, Pt.74), or coronary velocity reserve (2.7 vs 2.7, P=.82). CONCLUSION: This study shows that the postmenopausal state is associated with a greater abnormality in coronary endothelial function at the level of the microcirculation. Moreover, HRT status was not associated with an improvement in coronary endothelial function in postmenopausal woman.

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