Effect of lifestyle activities on alzheimer disease biomarkers and cognition

Prashanthi D Vemuri, Timothy G. Lesnick, Scott A. Przybelski, David S Knopman, Rosebud O Roberts, Val Lowe, Kejal M Kantarci, Mathew L. Senjem, Jeffrey L. Gunter, Bradley F Boeve, Ronald Carl Petersen, Clifford R Jr. Jack

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Abstract

Objective: A study was undertaken to investigate the association of intellectual and physical activity with biomarkers of Alzheimer disease (AD) pathophysiology and cognition in a nondemented elderly population. The biomarkers evaluated were brain Aβ load via Pittsburgh compound B (PiB)-positron emission tomography (PET), neuronal dysfunction via 18F-fluorodeoxyglucose (FDG)-PET, and neurodegeneration via structural magnetic resonance imaging (MRI). Methods: We studied 515 nondemented (428 cognitively normal and 87 mild cognitive impairment) participants in the population-based Mayo Clinic Study of Aging who completed a 3T MRI, PET scans, and APOE genotype, and had lifestyle activity measures and cognition data available. The imaging measures computed were global PiB-PET uptake, and global FDG-PET and MRI based hippocampal volume. We consolidated activity variables into lifetime intellectual, current intellectual, and current physical activities. We used a global cognitive z score as a measure of cognition. We applied 2 independent methods - partial correlation analysis adjusted for age and gender and path analysis using structural equations - to evaluate the associations between lifestyle activities, imaging biomarkers, and global cognition. Results: None of the lifestyle variables were correlated with the biomarkers, and the path associations between lifestyle variables and biomarkers were not significant (p > 0.05). Conversely, all the biomarkers were correlated with global cognitive z score (p< 0.05), and the path associations between (lifetime and current) intellectual activities and global z score were significant (p< 0.01). Interpretation: Intellectual and physical activity lifestyle factors were not associated with AD biomarkers, but intellectual lifestyle factors explained variability in the cognitive performance in this nondemented population. This study provides evidence that lifestyle activities may delay the onset of dementia but do not significantly influence the expression of AD pathophysiology.

Original languageEnglish (US)
Pages (from-to)730-738
Number of pages9
JournalAnnals of Neurology
Volume72
Issue number5
DOIs
StatePublished - Nov 2012

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Cognition
Life Style
Alzheimer Disease
Biomarkers
Positron-Emission Tomography
Magnetic Resonance Imaging
Exercise
Population
Fluorodeoxyglucose F18
Dementia
Genotype
Brain

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Effect of lifestyle activities on alzheimer disease biomarkers and cognition. / Vemuri, Prashanthi D; Lesnick, Timothy G.; Przybelski, Scott A.; Knopman, David S; Roberts, Rosebud O; Lowe, Val; Kantarci, Kejal M; Senjem, Mathew L.; Gunter, Jeffrey L.; Boeve, Bradley F; Petersen, Ronald Carl; Jack, Clifford R Jr.

In: Annals of Neurology, Vol. 72, No. 5, 11.2012, p. 730-738.

Research output: Contribution to journalArticle

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abstract = "Objective: A study was undertaken to investigate the association of intellectual and physical activity with biomarkers of Alzheimer disease (AD) pathophysiology and cognition in a nondemented elderly population. The biomarkers evaluated were brain Aβ load via Pittsburgh compound B (PiB)-positron emission tomography (PET), neuronal dysfunction via 18F-fluorodeoxyglucose (FDG)-PET, and neurodegeneration via structural magnetic resonance imaging (MRI). Methods: We studied 515 nondemented (428 cognitively normal and 87 mild cognitive impairment) participants in the population-based Mayo Clinic Study of Aging who completed a 3T MRI, PET scans, and APOE genotype, and had lifestyle activity measures and cognition data available. The imaging measures computed were global PiB-PET uptake, and global FDG-PET and MRI based hippocampal volume. We consolidated activity variables into lifetime intellectual, current intellectual, and current physical activities. We used a global cognitive z score as a measure of cognition. We applied 2 independent methods - partial correlation analysis adjusted for age and gender and path analysis using structural equations - to evaluate the associations between lifestyle activities, imaging biomarkers, and global cognition. Results: None of the lifestyle variables were correlated with the biomarkers, and the path associations between lifestyle variables and biomarkers were not significant (p > 0.05). Conversely, all the biomarkers were correlated with global cognitive z score (p< 0.05), and the path associations between (lifetime and current) intellectual activities and global z score were significant (p< 0.01). Interpretation: Intellectual and physical activity lifestyle factors were not associated with AD biomarkers, but intellectual lifestyle factors explained variability in the cognitive performance in this nondemented population. This study provides evidence that lifestyle activities may delay the onset of dementia but do not significantly influence the expression of AD pathophysiology.",
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AU - Vemuri, Prashanthi D

AU - Lesnick, Timothy G.

AU - Przybelski, Scott A.

AU - Knopman, David S

AU - Roberts, Rosebud O

AU - Lowe, Val

AU - Kantarci, Kejal M

AU - Senjem, Mathew L.

AU - Gunter, Jeffrey L.

AU - Boeve, Bradley F

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

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N2 - Objective: A study was undertaken to investigate the association of intellectual and physical activity with biomarkers of Alzheimer disease (AD) pathophysiology and cognition in a nondemented elderly population. The biomarkers evaluated were brain Aβ load via Pittsburgh compound B (PiB)-positron emission tomography (PET), neuronal dysfunction via 18F-fluorodeoxyglucose (FDG)-PET, and neurodegeneration via structural magnetic resonance imaging (MRI). Methods: We studied 515 nondemented (428 cognitively normal and 87 mild cognitive impairment) participants in the population-based Mayo Clinic Study of Aging who completed a 3T MRI, PET scans, and APOE genotype, and had lifestyle activity measures and cognition data available. The imaging measures computed were global PiB-PET uptake, and global FDG-PET and MRI based hippocampal volume. We consolidated activity variables into lifetime intellectual, current intellectual, and current physical activities. We used a global cognitive z score as a measure of cognition. We applied 2 independent methods - partial correlation analysis adjusted for age and gender and path analysis using structural equations - to evaluate the associations between lifestyle activities, imaging biomarkers, and global cognition. Results: None of the lifestyle variables were correlated with the biomarkers, and the path associations between lifestyle variables and biomarkers were not significant (p > 0.05). Conversely, all the biomarkers were correlated with global cognitive z score (p< 0.05), and the path associations between (lifetime and current) intellectual activities and global z score were significant (p< 0.01). Interpretation: Intellectual and physical activity lifestyle factors were not associated with AD biomarkers, but intellectual lifestyle factors explained variability in the cognitive performance in this nondemented population. This study provides evidence that lifestyle activities may delay the onset of dementia but do not significantly influence the expression of AD pathophysiology.

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