Effect of iontophoretic application of cholinergic agonists and their antagonists to guinea‐pig pelvic ganglia

MOLLIE E. HOLMAN, T. C. MUIR, J. H. SZURSZEWSKI, K. YONEMURA

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The electrical activity of guinea‐pig pelvic ganglion cells following iontophoretically applied cholinergic drugs, alone and during orthodromic nerve stimulation via the hypogastric nerve, has been recorded intracellularly. Iontophoretic application of nicotine (Nic) and acetylcholine (ACh) reduced membrane resistance and caused a depolarization which in approximately 80% of cells led to the firing of action potentials. In the remainder, depolarization was unaccompanied by firing. Iontophoretic application of Nic and ACh reduced or abolished the amplitude of successively evoked orthodromic responses. ACh‐induced depolarization, unlike that caused by tetanic stimulation, was not followed by a subsequent increase in the frequency of synaptic potentials. Di‐hydroβerythroidine (DHβE) and atropine (Atr) inhibited the response to both orthodromic stimulation and iontophoretic application of Nic and ACh. There was no evidence for the existence of muscarinic receptors in guinea‐pig pelvic ganglia. Iontophoretic application of muscarinic agonists alone and after tetanic stimulation of the hypogastric nerve produced no significant depolarization of the ganglion cell membrane. 1971 British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)26-40
Number of pages15
JournalBritish Journal of Pharmacology
Volume41
Issue number1
DOIs
StatePublished - Jan 1971

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Effect of iontophoretic application of cholinergic agonists and their antagonists to guinea‐pig pelvic ganglia'. Together they form a unique fingerprint.

Cite this