TY - JOUR
T1 - Effect of intermittent physiologic hyperglucagonemia on postprandial plasma glucose levels in normal man
AU - Mackes, K.
AU - Rizza, R.
AU - Gerich, J.
N1 - Funding Information:
From the Endocrine Hesearch Unit, Department oJ'Medicineand Physiology, Mayo Medical School and Mayo Clinic, Rochester. Minnesota. Received for publication May 28. 1980. Supported in part by grants from Deutsche Forschungsgemein-schaft. the National Institutes of Arthritis, Metabolism, and Digestive Diseases (AM2041 I. RR00036). the Maw Foundation and the March of Dimes. Address reprint requests to Dr. John Gerich. Endocrine Research Unit, Department of Medicine. Mayo Medical School. Mayo Clinic, Rochester, Minnesota 55905. :r 1981 by Grune & Stratton, Inc. 00260495/8//30/ 1-0001$01.00/0
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1981/11
Y1 - 1981/11
N2 - The ability of glucagon to impair glucose tolerance has been questioned by studies involving infusion of exogenous glucagon during a glucose load. Since such hormone administration may not reflect the physiologic pattern of glucagon secretion and may result in hepatic downregulation to glucagon, the present experiments have examined the effects of intermittent andogenous hyperglucagonemia (induced by episodic infusion of arginine) on plasma glucose profiles of normal man following ingestion of mixed meals. In control studies following meal ingestion, plasma glucose, insulin and glucagon increased respectively 15-30 mg/dl, 30-60 uU/ml and 25-50 pg/ml. When meals were accompanied by arginine infusions, plasma glucagon responses were augmented three to fourfold (p < 0.05). Amplitudes of glycemic excursions during infusion of arginine (345 ± 40 mg/dl) were significantly augmented compared to those observed in control studies (286 ± 34 mg/dl, p < 0.02). These results indicate that intermittent increases in plasma glucagon within the physiologic range can adversely affect postprandial glucose profiles in normal man despite concomitant hyperinsulinemia and suggest that such hyperglucagonemia may contribute to impaired postprandial glucose tolerance in diabetic individuals in whom insulin secretion is deficient.
AB - The ability of glucagon to impair glucose tolerance has been questioned by studies involving infusion of exogenous glucagon during a glucose load. Since such hormone administration may not reflect the physiologic pattern of glucagon secretion and may result in hepatic downregulation to glucagon, the present experiments have examined the effects of intermittent andogenous hyperglucagonemia (induced by episodic infusion of arginine) on plasma glucose profiles of normal man following ingestion of mixed meals. In control studies following meal ingestion, plasma glucose, insulin and glucagon increased respectively 15-30 mg/dl, 30-60 uU/ml and 25-50 pg/ml. When meals were accompanied by arginine infusions, plasma glucagon responses were augmented three to fourfold (p < 0.05). Amplitudes of glycemic excursions during infusion of arginine (345 ± 40 mg/dl) were significantly augmented compared to those observed in control studies (286 ± 34 mg/dl, p < 0.02). These results indicate that intermittent increases in plasma glucagon within the physiologic range can adversely affect postprandial glucose profiles in normal man despite concomitant hyperinsulinemia and suggest that such hyperglucagonemia may contribute to impaired postprandial glucose tolerance in diabetic individuals in whom insulin secretion is deficient.
UR - http://www.scopus.com/inward/record.url?scp=0019455417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019455417&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(81)90045-7
DO - 10.1016/0026-0495(81)90045-7
M3 - Article
C2 - 7026969
AN - SCOPUS:0019455417
SN - 0026-0495
VL - 30
SP - 1041
EP - 1044
JO - Metabolism
JF - Metabolism
IS - 11
ER -