@article{7285ae959e5a43e6b3b1ffa0ba8abfa3,
title = "Effect of initial treatment on health-related quality of life in patients with newly diagnosed multiple myeloma without immediate stem cell transplant intent: results from the Connect{\textregistered} MM Registry",
abstract = "Although new multiple myeloma (MM) therapies are effective in alleviating some disease-associated symptoms (e.g. bone pain, fatigue, functional decline), they can result in additional toxicities, further impacting health-related quality of life (HRQoL). Here, we compared HRQoL and safety of lenalidomide-bortezomib-dexamethasone [RVd (n = 445)], bortezomib-melphalan-prednisone [VMP (n = 77)] and Vd or VMP (n = 588) in patients with newly diagnosed MM (NDMM) from the Connect{\textregistered} MM Registry, a large, USA, multicentre, prospective observational cohort study. Functional Assessment of Cancer Therapy-Multiple Myeloma subscale, EuroQol-5D overall score and Bone Pain Inventory HRQoL scores were significantly improved with RVd versus Vd/VMP. Serious adverse event rates were similar in all groups. Treatment with RVd maintained HRQoL in this real-world, largely community-based population of patients with NDMM.",
keywords = "health-related quality of life, lenalidomide, multiple myeloma, real-world evidence",
author = "{the CONNECT MM Registry Investigators} and Rafat Abonour and Rifkin, {Robert M.} and Cristina Gasparetto and Kathleen Toomey and Durie, {Brian G.M.} and Hardin, {James W.} and Terebelo, {Howard R.} and Sundar Jagannath and Mohit Narang and Sikander Ailawadhi and Omel, {James L.} and Lee, {Hans C.} and Shankar Srinivasan and Amani Kitali and Amit Agarwal and Lynne Wagner",
note = "Funding Information: This study was funded by Celgene Corporation, and is currently supported by Bristol Myers Squibb. Rafat Abonour: member of steering committees for Celgene, a Bristol Myers Squibb Company and Takeda, research funding from Celgene, a Bristol Myers Squibb Company, Takeda and Prothena. Robert M. Rifkin: consultancy services to Amgen, Boehringer Ingelheim, Celgene, a Bristol Myers Squibb Company, EMD Serono, Sandoz and Takeda and owns stock with McKesson. Cristina Gasparetto: honoraria from Janssen, Bristol Myers Squibb, Celgene, a Bristol Myers Squibb Company and Takeda; provided consultancy services to Janssen, Bristol Myers Squibb and Celgene, a Bristol Myers Squibb Company; travel reimbursement from Janssen, Bristol Myers Squibb and Celgene, a Bristol Myers Squibb Company; and research funding from Celgene. Kathleen Toomey: consultancy services to Celgene, a Bristol Myers Squibb Company. Brian G. M. Durie: consultancy services to Takeda and Janssen. James W. Hardin: consultancy services to Celgene, a Bristol Myers Squibb Company. Howard R. Terebelo: consultancy services to Celgene, a Bristol Myers Squibb Company and participated in speakers{\textquoteright} bureaus for Janssen, Takeda and Pharmacyclics LLC, an AbbVie Company. Sundar Jagannath: consultancy services to Celgene, a Bristol Myers Squibb Company, Bristol Myers Squibb, Novartis and Merck and speakers{\textquoteright} bureaus for MMRF and Medicom. Mohit Narang: consultancy services and speakers{\textquoteright} bureaus for Celgene, a Bristol Myers Squibb Company and speakers{\textquoteright} bureaus for Janssen. Sikander Ailawadhi: consultancy services to Takeda, Novartis, Celgene, a Bristol Myers Squibb Company and Amgen, and research funding from Pharmacyclics, LLC, an AbbVie Company. James L. Omel: honoraria from Takeda Oncology and Celgene, a Bristol Myers Squibb Company, and on the board of directors/advisory committee for Takeda Oncology and Celgene, a Bristol Myers Squibb Company. Hans C. Lee: consultancy services for Adaptive Biotechnologies, Amgen, Celgene, a Bristol Myers Squibb Company, GlaxoSmithKline, Janssen, Sanofi and Takeda Pharmaceutical, and research funding from Amgen, Celgene, a Bristol Myers Squibb Company, Daiichi Sankyo, Eutropics Pharmaceuticals, GlaxoSmithKline, Janssen Pharmaceutical and Takeda Pharmaceutical. Shankar Srinivasan, Amani Kitali and Amit Agarwal: employed by Bristol Myers Squibb. Lynne Wagner: consultancy services to EveryFit, Gilead and Janssen. Publisher Copyright: {\textcopyright} 2020 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd",
year = "2021",
month = apr,
doi = "10.1111/bjh.17131",
language = "English (US)",
volume = "193",
pages = "93--100",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "1",
}