Effect of inhaled methacholine on inspiratory flow

J. M. Kelso, P. L. Enright, Paul D Scanlon, E. J. O'Connell, M. I. Sachs

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

One hundred consecutive outpatients with symptoms suggestive of asthma who came to the Pulmonary Function Laboratory for a methacholine challenge test were studied. In addition to the forced expiratory maneuvers, forced inspiratory maneuvers were performed before and after the maximal response to methacholine. In 24 patients, the methacholine challenge suggested that they had asthma (forced expiratory volume in 1 s [FEV1] decrease ≥20 percent). Six of these 24 patients also had a decrease in maximal forced inspiratory flow (FIFmax) ≥20 percent and nine had a decrease in forced inspiratory flow at 50 percent of vital capacity (FIF50) ≥20 percent, suggesting that bronchoconstriction can cause decreased inspiratory as well as expiratory flows. In 76 patients, the methacholine challenges were 'negative' (FEV1 decrease ≤20 percent), suggesting that they did not have asthma. Nevertheless, in 11 of these 76 patients the FIFmax decrease was ≥20 percent, and in 14 patients the FIF50 decrease was ≥20 percent, suggesting that intermittent central airway obstruction is responsible for these patient's symptoms.

Original languageEnglish (US)
Pages (from-to)1426-1429
Number of pages4
JournalChest
Volume98
Issue number6
StatePublished - 1990

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Methacholine Chloride
Asthma
Forced Expiratory Volume
Bronchoconstriction
Vital Capacity
Airway Obstruction
Outpatients
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Kelso, J. M., Enright, P. L., Scanlon, P. D., O'Connell, E. J., & Sachs, M. I. (1990). Effect of inhaled methacholine on inspiratory flow. Chest, 98(6), 1426-1429.

Effect of inhaled methacholine on inspiratory flow. / Kelso, J. M.; Enright, P. L.; Scanlon, Paul D; O'Connell, E. J.; Sachs, M. I.

In: Chest, Vol. 98, No. 6, 1990, p. 1426-1429.

Research output: Contribution to journalArticle

Kelso, JM, Enright, PL, Scanlon, PD, O'Connell, EJ & Sachs, MI 1990, 'Effect of inhaled methacholine on inspiratory flow', Chest, vol. 98, no. 6, pp. 1426-1429.
Kelso JM, Enright PL, Scanlon PD, O'Connell EJ, Sachs MI. Effect of inhaled methacholine on inspiratory flow. Chest. 1990;98(6):1426-1429.
Kelso, J. M. ; Enright, P. L. ; Scanlon, Paul D ; O'Connell, E. J. ; Sachs, M. I. / Effect of inhaled methacholine on inspiratory flow. In: Chest. 1990 ; Vol. 98, No. 6. pp. 1426-1429.
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