Effect of in-painting on cortical thickness measurements in multiple sclerosis: A large cohort study

MRI Analysis Center at Houston; The CombiRx Investigators Group

doi:10.1002/hbm.22875

Effect of in-painting on cortical thickness measurements in multiple sclerosis: A large cohort study

MRI Analysis Center at Houston, The CombiRx Investigators Group

Neurology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ~2%. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness.

Original language	English (US)
Pages (from-to)	3749-3760
Number of pages	12
Journal	Human Brain Mapping
Volume	36
Issue number	10
DOIs	https://doi.org/10.1002/hbm.22875
State	Published - Oct 1 2015

Keywords

Cortical thickness
FreeSurfer
Lesion in-painting
Multiple sclerosis
Multiple sclerosis lesions

ASJC Scopus subject areas

Anatomy
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Neurology
Clinical Neurology

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10.1002/hbm.22875

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@article{8507df2176f04941a841fb935edd4d91,

title = "Effect of in-painting on cortical thickness measurements in multiple sclerosis: A large cohort study",

abstract = "A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ~2%. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness.",

keywords = "Cortical thickness, FreeSurfer, Lesion in-painting, Multiple sclerosis, Multiple sclerosis lesions",

author = "{MRI Analysis Center at Houston} and {The CombiRx Investigators Group} and Govindarajan, {Koushik A.} and Sushmita Datta and Hasan, {Khader M.} and Sangbum Choi and Rahbar, {Mohammad H.} and Cofield, {Stacey S.} and Cutter, {Gary R.} and Lublin, {Fred D.} and Wolinsky, {Jerry S.} and Narayana, {Ponnada A.} and F. Nelson and I. Vainrub and R. He and B. Gates and K. Ton and M. Agius and K. Bashir and R. Baumhefner and G. Birnbaum and G. Blevins and R. Bomprezzi and A. Boster and T. Brown and J. Burkholder and A. Camac and D. Campagnolo and J. Carter and B. Cohen and J. Cooper and J. Corboy and A. Cross and L. Dewitt and J. Dunn and K. Edwards and E. Eggenberger and J. English and W. Felton and P. Fodor and C. Ford and M. Freedman and S. Galetta and G. Garmany and A. Goodman and M. Gottesman and C. Gottschalk and M. Gruental and M. Gudesblatt and R. Hamill and J. Herbert and R. Holub",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley Periodicals, Inc.",

year = "2015",

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doi = "10.1002/hbm.22875",

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T1 - Effect of in-painting on cortical thickness measurements in multiple sclerosis

T2 - A large cohort study

AU - MRI Analysis Center at Houston

AU - The CombiRx Investigators Group

AU - Govindarajan, Koushik A.

AU - Datta, Sushmita

AU - Hasan, Khader M.

AU - Choi, Sangbum

AU - Rahbar, Mohammad H.

AU - Cofield, Stacey S.

AU - Cutter, Gary R.

AU - Lublin, Fred D.

AU - Wolinsky, Jerry S.

AU - Narayana, Ponnada A.

AU - Nelson, F.

AU - Vainrub, I.

AU - He, R.

AU - Gates, B.

AU - Ton, K.

AU - Agius, M.

AU - Bashir, K.

AU - Baumhefner, R.

AU - Birnbaum, G.

AU - Blevins, G.

AU - Bomprezzi, R.

AU - Boster, A.

AU - Brown, T.

AU - Burkholder, J.

AU - Camac, A.

AU - Campagnolo, D.

AU - Carter, J.

AU - Cohen, B.

AU - Cooper, J.

AU - Corboy, J.

AU - Cross, A.

AU - Dewitt, L.

AU - Dunn, J.

AU - Edwards, K.

AU - Eggenberger, E.

AU - English, J.

AU - Felton, W.

AU - Fodor, P.

AU - Ford, C.

AU - Freedman, M.

AU - Galetta, S.

AU - Garmany, G.

AU - Goodman, A.

AU - Gottesman, M.

AU - Gottschalk, C.

AU - Gruental, M.

AU - Gudesblatt, M.

AU - Hamill, R.

AU - Herbert, J.

AU - Holub, R.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ~2%. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness.

AB - A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ~2%. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness.

KW - Cortical thickness

KW - FreeSurfer

KW - Lesion in-painting

KW - Multiple sclerosis

KW - Multiple sclerosis lesions

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JO - Human Brain Mapping

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ER -

Effect of in-painting on cortical thickness measurements in multiple sclerosis: A large cohort study

Abstract

Keywords

ASJC Scopus subject areas

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