Effect of hyperglycemia on brain pH levels in areas of focal incomplete cerebral ischemia in monkeys

W. R. Marsh, R. E. Anderson, T. M. Sundt

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The adverse effect of a minimal cerebral blood flow (CBF) in models of global ischemia has been noted by many investigators. One factor believed important in this situation is the level of blood glucose, since a continued supply of this metabolite results in increased tissue lactate, decreased brain pH, and increased cell damage. The authors have extended these observations to a model of focal incomplete ischemia. Brain pH was measured in fasted squirrel monkeys in regions of focal incomplete ischemia after transorbital occlusion of the middle cerebral artery (MCA). In both control and hyperglycemic animals, CBF was reduced to less than 30% of baseline. At 3 hours after MCA occlusion, brain pH in the control group was 6.66 ± 0.68 as compared to 6.27 ± 0.26 in the glucose-treated group. This difference was statistically significant by Student's unpaired t-test (p < 0.05). Thus, hyperglycemia results in decreased tissue pH in regions of focal incomplete cerebral ischemia in monkeys.

Original languageEnglish (US)
Pages (from-to)693-696
Number of pages4
JournalJournal of Neurosurgery
Volume65
Issue number5
StatePublished - 1986

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Brain Ischemia
Hyperglycemia
Haplorhini
Cerebrovascular Circulation
Ischemia
Middle Cerebral Artery Infarction
Brain
Saimiri
Blood Glucose
Lactic Acid
Research Personnel
Students
Glucose
Control Groups

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)
  • Clinical Neurology

Cite this

Effect of hyperglycemia on brain pH levels in areas of focal incomplete cerebral ischemia in monkeys. / Marsh, W. R.; Anderson, R. E.; Sundt, T. M.

In: Journal of Neurosurgery, Vol. 65, No. 5, 1986, p. 693-696.

Research output: Contribution to journalArticle

Marsh, W. R. ; Anderson, R. E. ; Sundt, T. M. / Effect of hyperglycemia on brain pH levels in areas of focal incomplete cerebral ischemia in monkeys. In: Journal of Neurosurgery. 1986 ; Vol. 65, No. 5. pp. 693-696.
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