Abstract
Human leukocyte antigen (HLA) genes play a critical role in host immunity, including vaccine responses. HLA molecules present antigenic peptides to T cells and provide inhibitory signals to NK cells, and polymorphisms within HLA genes allow binding and presentation of a diverse array of self and foreign peptides. Heterozygosity across HLA alleles has been found to play a positive role in host defense for a variety of infections. Homozygosity within one or more HLA loci may restrict this epitope repertoire and limit T-cell responses to infection or vaccination. Here we report that homozygosity within the HLA DPB1 locus is associated with increased levels of rubella-specific IgG, an effect driven by a common allele DPB1*0401. We also show that homozygosity within different HLA class I and class II loci is correlated with variations (but not necessarily decreases) in interleukin (IL)-2, IL-5, and IL-10 secretion after rubella virus stimulation.
Original language | English (US) |
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Pages (from-to) | 128-135 |
Number of pages | 8 |
Journal | Human Immunology |
Volume | 71 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2010 |
Keywords
- HLA antigens
- Homozygote
- Immunity
- Measles-mumps-rubella vaccine
- Rubella virus
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology