Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses

Richard B. Kennedy, Inna G. Ovsyannikova, Robert A. Vierkant, Robert M. Jacobson, Gregory A. Poland

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Human leukocyte antigen (HLA) genes play a critical role in host immunity, including vaccine responses. HLA molecules present antigenic peptides to T cells and provide inhibitory signals to NK cells, and polymorphisms within HLA genes allow binding and presentation of a diverse array of self and foreign peptides. Heterozygosity across HLA alleles has been found to play a positive role in host defense for a variety of infections. Homozygosity within one or more HLA loci may restrict this epitope repertoire and limit T-cell responses to infection or vaccination. Here we report that homozygosity within the HLA DPB1 locus is associated with increased levels of rubella-specific IgG, an effect driven by a common allele DPB1*0401. We also show that homozygosity within different HLA class I and class II loci is correlated with variations (but not necessarily decreases) in interleukin (IL)-2, IL-5, and IL-10 secretion after rubella virus stimulation.

Original languageEnglish (US)
Pages (from-to)128-135
Number of pages8
JournalHuman Immunology
Volume71
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • HLA antigens
  • Homozygote
  • Immunity
  • Measles-mumps-rubella vaccine
  • Rubella virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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