Abstract
An ex vivo model of a perfused canine tibia was used to investigate the effect of human adrenomedullin, a novel peptide with known vasodilator properties, on the vascular resistance of bone. Human adrenomedullin has a potent and long-lasting vasodilator effect in the canine tibia following precontraction of vascular smooth muscle by infusion of prostaglandin F(2α). A 0.1 ml bolus injection of 10-5 M human adrenomedullin suppressed the pressor response of the canine tibia preparation to an infusion of norepinephrine by 43-52% for a duration of 100 minutes. An injection of 10- 6 adrenomedullin suppressed the pressor response to an infusion of norepinephrine by 22-23% for a duration of 40 minutes. These data suggest that human adrenomedullin may be a potent and long-acting vascular smooth muscle relaxant in bone.
Original language | English (US) |
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Pages (from-to) | 329-333 |
Number of pages | 5 |
Journal | Journal of Orthopaedic Research |
Volume | 14 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1996 |
ASJC Scopus subject areas
- Orthopedics and Sports Medicine