Effect of human adrenomedullin on vascular resistance of the canine tibia

T. Kato, A. T. Bishop, M. B. Wood, M. L. Adams

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

An ex vivo model of a perfused canine tibia was used to investigate the effect of human adrenomedullin, a novel peptide with known vasodilator properties, on the vascular resistance of bone. Human adrenomedullin has a potent and long-lasting vasodilator effect in the canine tibia following precontraction of vascular smooth muscle by infusion of prostaglandin F(2α). A 0.1 ml bolus injection of 10-5 M human adrenomedullin suppressed the pressor response of the canine tibia preparation to an infusion of norepinephrine by 43-52% for a duration of 100 minutes. An injection of 10- 6 adrenomedullin suppressed the pressor response to an infusion of norepinephrine by 22-23% for a duration of 40 minutes. These data suggest that human adrenomedullin may be a potent and long-acting vascular smooth muscle relaxant in bone.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalJournal of Orthopaedic Research
Volume14
Issue number2
DOIs
StatePublished - Mar 1 1996

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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