Effect of hormone variations and other factors on symptom severity in women with dystonia

Katrina A. Gwinn-Hardy, Charles Howard Adler, Amy L. Weaver, Nancy M. Fish, Stephanie J. Newman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Objective: To determine if any relationship exists between the severity of symptoms in women with dystonia and female reproductive hormonal variations. Patients and Methods: We surveyed 279 women with dystonia seen at Mayo Clinic Scottsdale over a 6-year period (1990-1995), and 204 responded. The women were asked questions regarding their reproductive and menstrual histories and dystonia severity and other questions with an emphasis on possible exacerbating or relieving factors. Results: Although in the majority of women hormonal influences had no consistent effect on dystonia symptom severity, 26 (41.9%) of 62 premenopausal women noted a change in the severity of their dystonic symptoms in relation to the 3 phases of their menstrual cycle. Other factors that exacerbated dystonia included stress and fatigue, while sleep improved symptoms. Pregnancy, menopause, and hormone replacement therapy had no effect on symptoms. Conclusions: Menstrual cycling may result in subjective worsening of dystonia symptoms in some women with dystonia. Further clinical and physiologic evaluation is indicated in such patients, as they may represent an important subgroup of dystonic patients that might yield some clues to the pathophysiology of dystonia and to improved treatment strategies.

Original languageEnglish (US)
Pages (from-to)235-240
Number of pages6
JournalMayo Clinic Proceedings
Volume75
Issue number3
StatePublished - 2000

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gwinn-Hardy, K. A., Adler, C. H., Weaver, A. L., Fish, N. M., & Newman, S. J. (2000). Effect of hormone variations and other factors on symptom severity in women with dystonia. Mayo Clinic Proceedings, 75(3), 235-240.